+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Tumor cyto toxic activity of resident rat macrophages

Tumor cyto toxic activity of resident rat macrophages

Journal of the Reticuloendothelial Society 29(5): 369-380

Adherent, phagocytic cells from the unstimulated peritoneal cavities and lungs of 5 rat stains were tested for their tumor-cytotoxic capabilities using an in vitro [3H]thymidine release assay. The cells had cytotoxic activity, which varied with the effector:target ratio, against 4 of 8 allogeneic and xenogeneic cell lines tested; cytotoxicity was only evident against tumor cells expressing viral Ag [antigens]. The effector cell was radioresistant, sensitive to carrageenan treatment and required 24-48 h to express cytotoxic activity. Because nonadherent peritoneal or spleen cells were not cytotoxic for any of the tumor lines tested, cytotoxicity was probably due to macrophages [MP] and not natural killer cells. The cytotoxicity could not be attributed to MP activation via infection because MP from germfree and conventional-flora rats had comparable cytotoxic activities. The cytotoxicity was abrogated by extended time in culture and polymyxin B. Resident MP which were occasionally not cytotoxic became cytotoxic in the presence of endotoxin or lymphokines, but only for tumor cells expressing viral Ag. Thus, resident rat MP apparently possess a restricted ability to kill allogeneic and xenogeneic tumor cells in vitro.

(PDF 0-2 workdays service: $29.90)

Accession: 006846729

Download citation: RISBibTeXText

PMID: 7241409

Related references

Cyto toxic and phagocytic activity of human tumor infiltrating macrophages. British Journal of Cancer 38(1): 196, 1978

Effect of interleukin 2 on cyto toxic effectors 1. short term culture of cyto toxic effectors and in vivo anti tumor activity of cultured effectors isolated from the tumor site. International Journal of Cancer 30(5): 625-632, 1982

Specific elimination of cyto toxic cells part 2 reduction of cyto toxic activity by adsorption on mono layers results from removal of cyto toxic cells and not from inhibition of their activity. Cellular Immunology 29(1): 129-136, 1977

The nature of the effector cell in antibody dependent cell mediated cytolysis the cyto toxic activity of murine tumor cells and peritoneal macrophages. Clinical Immunology & Immunopathology 5(2): 272-281, 1976

Evaluation of the immuno competence of macrophages and the generation of thymus derived cell mediated cyto toxic response against allogeneic tumor cells in tumor bearers. International Journal of Cancer 25(2): 243-250, 1980

In vitro induction of cell mediated immunity to murine leukemia cells part 2 cyto toxic activity in vitro and tumor neutralizing capacity in vivo of anti leukemia cyto toxic lymphocytes generated in macro cultures. Journal of Immunological Methods 16(1): 39-58, 1977

Cyto toxic action of macrophages activated by bcg on tumor target cells in vitro. Bulletin of Experimental Biology & Medicine 87(1): 42-45, 1979

Macrophage activation for tumor cyto toxicity control of cyto toxic activity by the time interval effector and target cells are exposed to lymphokines. Cellular Immunology 65(1): 52-65, 1981

In vitro study of the cyto toxic effect of bcg activated macrophages on tumor target cell. Byulleten' Eksperimental'noi Biologii i Meditsiny 87(1): 36-39, 1979

Characterization of macrophage activation factor a lymphokine that causes macrophages to become cyto toxic for tumor cells. Cellular Immunology 41(2): 347-357, 1978

Inability of tumor cells to elicit the respiratory burst in cyto toxic activated macrophages. Immunology 45(3): 577-586, 1982

Cyto toxic macrophages induced in hamsters by vaccinia virus selective cyto toxicity for virus infected targets by macrophages collected late after immunization. Journal of Immunology 123(1): 303-310, 1979

Novel cyto toxic and anti tumor agents 4. withaferin a relation of its structure to the in vitro cyto toxic effects on p 388 cells. Neoplasma (Bratislava) 31(1): 31-36, 1984

Direct and antibody dependent cyto toxic effect of rat pulmonary macrophages on syngeneic tumor cells/. Studii si Cercetari de Biologie 29(1): 31-34, 1977

The differential effects of prostaglandins on the cytostatic and cyto toxic activity of activated macrophages. Abstracts of the Annual Meeting of the American Society for Microbiology 80: ABSTRACT 1737, 1980