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Tumor cyto toxic activity of resident rat macrophages

Tumor cyto toxic activity of resident rat macrophages

Journal of the Reticuloendothelial Society 29(5): 369-380

Adherent, phagocytic cells from the unstimulated peritoneal cavities and lungs of 5 rat stains were tested for their tumor-cytotoxic capabilities using an in vitro [3H]thymidine release assay. The cells had cytotoxic activity, which varied with the effector:target ratio, against 4 of 8 allogeneic and xenogeneic cell lines tested; cytotoxicity was only evident against tumor cells expressing viral Ag [antigens]. The effector cell was radioresistant, sensitive to carrageenan treatment and required 24-48 h to express cytotoxic activity. Because nonadherent peritoneal or spleen cells were not cytotoxic for any of the tumor lines tested, cytotoxicity was probably due to macrophages [MP] and not natural killer cells. The cytotoxicity could not be attributed to MP activation via infection because MP from germfree and conventional-flora rats had comparable cytotoxic activities. The cytotoxicity was abrogated by extended time in culture and polymyxin B. Resident MP which were occasionally not cytotoxic became cytotoxic in the presence of endotoxin or lymphokines, but only for tumor cells expressing viral Ag. Thus, resident rat MP apparently possess a restricted ability to kill allogeneic and xenogeneic tumor cells in vitro.

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Accession: 006846729

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PMID: 7241409

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