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Tumor cyto toxicity of human macrophages after incubation with synthetic analogs of 2 lyso phosphatidyl choline



Tumor cyto toxicity of human macrophages after incubation with synthetic analogs of 2 lyso phosphatidyl choline



Journal of the National Cancer Institute 72(1): 53-60



Human alveolar macrophages as well as macrophages derived from Teflon culture of blood-borne monocytes were incubated with synthetic analogs of 2-lysophosphatidylcholine and then tested for their cytotoxic capacity against an allogenic lymphoma cell line [u 937-subclone 4]. Metabolic, rather stable analogs enhanced macrophage cytotoxicity significantly. This phenomenon was shown both in a growth-inhibition assay as well as in the 51Cr release assay. Macrophage activation was dose- and time-dependent and was potentiated at temperatures above 37.degree. C. Incubation of the macrophages with the active compounds induced characteristic changes in cell morphology as revealed by scanning electron microscopy.

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Accession: 006846730

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