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Tumor inhibition by metallocenes anti tumor activity of titanocene di halides and their application in buffered solutions as a method for suppressing drug induced side effects



Tumor inhibition by metallocenes anti tumor activity of titanocene di halides and their application in buffered solutions as a method for suppressing drug induced side effects



Journal of Cancer Research and Clinical Oncology 97(1): 31-40



The antitumor activity of titanocene dihalides (C5H5)2TiX2 with X = F, Cl, Br, I, NCS is investigated against [mouse] Ehrlich ascites tumor cells in CF 1 mice. Varying doses of the compounds are applied as single i.p. injections 24 h p.t.t [post-tumor transplantation] in non-buffered (pH 1.4-3.9) and buffered (pH 4.2-5.9) solutions or suspensions, all of the substances achieving in optimum doses cure rates of 100% on day 120 p.t.t. This corresponds to ILS [increase in life span] values of 600-750% compared to the untreated controls. Some drug-induced side effects, especially the appearance of postperitonitic symptoms several weeks after i.p. application of higher doses of titanocene dihalides, are strikingly reduced by pH elevation in the injected drug solutions.

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