+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Two types of antimutagenic effects of gallic and tannic acids towards n nitroso compound induced mutagenicity in the ames salmonella assay



Two types of antimutagenic effects of gallic and tannic acids towards n nitroso compound induced mutagenicity in the ames salmonella assay



Folia Microbiologica 32(1): 55-62



The frequency of his+ revertants induced by N-methyl-N-nitrosourea (MNU) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the strain TA100 of Salmonella typhimurium was decreased by gallic and tannic acid. In weak buffer solutions, the inhibition effects of gallic acid towards MNU and MNNG mutagenicity was caused primarily by a decrease of pH in the incubation mixtures. At adjusted pH (pH 5.0 and 6.5), the antimutagenic effects are largely the result of an interaction between MNU or MNNG with phenolic acids outside the cells.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006851178

Download citation: RISBibTeXText

PMID: 3546027


Related references

Mutagenicity tests with gallic and tannic acid in the Salmonella/mammalian microsome assay. Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes 20(2): 153-165, 1985

Mutagenicity tests with gallic acid and tannic acid in the salmonella typhimurium mammalian microsome assay. Journal of Environmental Science & Health Part B Pesticides Food Contaminants & Agricultural Wastes 20(2): 153-166, 1985

Antimutagenic, Antigenotoxic, and Anticytotoxic Activities of Silybum Marianum [L.] Gaertn Assessed by the Salmonella Mutagenicity Assay (Ames Test) and the Micronucleus Test in Mice Bone Marrow. Nutrition and Cancer 68(5): 848-855, 2018

Antimutagenic effects of diethyldithiocarbamate towards maleic hydrazide and n nitrosodiethylamine induced mutagenicity in the tradescantia mutagenicity assay. Biologia Plantarum (Prague) 30(1): 14-19, 1988

Structure-activity relationship of nitroalkane-induced mutagenicity in the Ames Salmonella assay. Progress in Clinical and Biological Research 209b: 149-155, 1986

Diverse mutagenicity of methylbenz[c]acridines in the direct Ames' Salmonella mutagenicity assay. Anticancer Research 16(5a): 2837-2841, 1996

Confidence limits for mutagenicity of weak mutagens in the ames salmonella mutagenicity assay. Environmental Mutagenesis 3(3): 367, 1981

Detection of antimutagenic compounds by ames salmonella assay. Environmental & Molecular Mutagenesis Supplement 15(17): 40, 1990

Effects of concentration of limiting amino acid upon mutagenicity in the ames salmonella typhimurium microsome assay. Environmental Mutagenesis 3(3): 388, 1981

Evaluation of the genotoxic potential of zinc pyrithione in the Salmonella mutagenicity (Ames) assay, CHO/HGPRT gene mutation assay and mouse micronucleus assay. Journal of Applied Toxicology 13(4): 283-289, 1993