Ultrastructural changes in guinea pig's epidermis 24 hours after stripping off the stratum corneum

Charvat, Z.; Noronha, C.

Folia Morphologica 29(4): 415-420


ISSN/ISBN: 0015-5640
PMID: 7319419
Accession: 006856974

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After stripping off the stratum corneum a well developed intraepidermal edema was observed which caused the disrupture of many desmosomes in the Malpighian layer. Whole degenerating desmosomes were engulfed in a kind of a digestive chamber produced by outgrowth of cytoplasmic leaflets of one of the 2 neighboring keratinocytes. As a defense against the edema many slender fingerlike microprocesses grew out of the damaged keratinocytes filling the enlarged intraepidermal spaces. Later new desmosomes were developed where the processes touched each other. The newly developed tonofilaments were conspicuously electrondense and closely packed. Membrane coating granules (Odland bodies) were observed in the developing stratum granulosum. These granules exist in 2 different forms: small rounded electrodense bodies with a central or excentrical lighting and oval bodies and a typical lamellation. The unit membrane of these bodies fused with the plasmalemma of the keratinocytes and their contents was discharged into the intercellular space; mainly in the stratum granulosum. The functions of membrane coating granules were discussed.