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Ultrastructural changes in pseudomonas aeruginosa cells under the effect of gentamicin in vitro and in vivo



Ultrastructural changes in pseudomonas aeruginosa cells under the effect of gentamicin in vitro and in vivo



Antibiotiki (Moscow) 28(3): 199-204



Morphological changes in phagocytosed cells of P. aeruginosa under the effect of gentamicin were studied by EM using ultrathin slices. Peritoneal macrophages induced by irritation of the peritoneum with medium 199 followed by inoculation with a suspension of P. aeruginosa were used. Gentamicin was administered in single doses of 10, 20 and 50 mg/kg. The effect of gentamicin on P. aeruginosa was also studied in vitro; genetamicin induced rarefaction of the cytoplasm, elimination of the nuclear material, formation of membrane structures and separation of the cytoplasmic membrane from the cell wall. Exposure of phagocytosed bacteria to gentamicin had the most pronounced effect on ultrastructure. Under the effect of gentamicin in a dose of 50 mg/kg, 2 morphologies not observed in vitro were seen. Investigation of the digestive capacity of phagocytes demonstrated that gentamicin increased phagocytic activity and digestive capacity.

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Accession: 006857068

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