+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Ultrastructural changes in pseudomonas aeruginosa cells under the effect of gentamicin in vitro and in vivo

Ultrastructural changes in pseudomonas aeruginosa cells under the effect of gentamicin in vitro and in vivo

Antibiotiki (Moscow) 28(3): 199-204

Morphological changes in phagocytosed cells of P. aeruginosa under the effect of gentamicin were studied by EM using ultrathin slices. Peritoneal macrophages induced by irritation of the peritoneum with medium 199 followed by inoculation with a suspension of P. aeruginosa were used. Gentamicin was administered in single doses of 10, 20 and 50 mg/kg. The effect of gentamicin on P. aeruginosa was also studied in vitro; genetamicin induced rarefaction of the cytoplasm, elimination of the nuclear material, formation of membrane structures and separation of the cytoplasmic membrane from the cell wall. Exposure of phagocytosed bacteria to gentamicin had the most pronounced effect on ultrastructure. Under the effect of gentamicin in a dose of 50 mg/kg, 2 morphologies not observed in vitro were seen. Investigation of the digestive capacity of phagocytes demonstrated that gentamicin increased phagocytic activity and digestive capacity.

(PDF 0-2 workdays service: $29.90)

Accession: 006857068

Download citation: RISBibTeXText

Related references

Ultrastructural changes in Pseudomonas aeruginosa cells as affected by gentamycin in in vitro and in vivo experiments. Antibiotiki 28(3): 199-204, 1983

Ultrastructural changes in pseudomonas aeruginosa cells caused by amikacin gentamicin and sisomicin. Siegenthaler, Walter And Ruedi Luethy (Ed ) Current Chemotherapy Proceedings Of The 10th International Congress Of Chemotherapy, Vols I And Ii Zurich, Switzerland, Sept 18-23, 1977 Xxiv+736p (Vol I); 625p (Vol Ii) Illus American Society For Microbiology: Washington, D C , Usa Isbn 0-914826-16-6 457-460, 1978

Tolerance of Pseudomonas aeruginosa to killing by ciprofloxacin, gentamicin and imipenem in vitro and in vivo. Journal of Antimicrobial ChemoTherapy 21(4): 395-404, 1988

The effect of triethylenetetramine dihydrochloride on the in vivo susceptibility of Pseudomonas aeruginosa to gentamicin. Journal of Antibiotics 32(8): 834-838, 1979

Effect of the concentrations of magnesium and calcium on the in-vitro susceptibility of Pseudomonas aeruginosa to gentamicin. Journal of Infectious Diseases 124 Suppl: S37-S45, 1971

Surface properties of cells of gentamicin-sensitive and gentamicin-resistant strains of Pseudomonas aeruginosa. Microbios 10a Suppl(41): 111-126, 1974

The carbenicillin-gentamicin combination against Pseudomonas aeruginosa. Correlation of effect with gentamicin sensitivity. Annals of Internal Medicine 81(5): 584-587, 1974

Effect of subinhibitory concentrations of Ciprofloxacin and gentamicin on the adherence of Pseudomonas aeruginosa to Vero cells and voided uroepithelial cells. ChemoTherapy 39(2): 105-111, 1993

An in vitro study on the effect of benzoyl peroxide 20%, gentamicin and phenoxyethanol on Staphylococcus aureus, Pseudomonas aeruginosa and Proteus species. Acta Dermato-Venereologica 59(6): 555-556, 1979

The effect of antimicrobial combinations on the in vitro activity of gentamicin against Klebsiella pneumoniae, Enterobacter cloacae, and Pseudomonas aeruginosa isolates. Abstracts of the General Meeting of the American Society for Microbiology 96(0): 142, 1996

Protective effect of quercetin in gentamicin-induced oxidative stress in vitro and in vivo in blood cells. Effect on gentamicin antimicrobial activity. Environmental Toxicology and Pharmacology 48(): 253-264, 2016

Combined gentamicin tobramycin cortico steroid treatment 2. effect on gentamicin resistant pseudomonas aeruginosa keratitis. Archives of Ophthalmology 98(3): 473-474, 1980

An in vitro study on the effect of benzoyl per oxide 20 percent gentamicin and phenoxy ethanol on staphylococcus aureus pseudomonas aeruginosa and proteus spp. Acta Dermato-Venereologica 59(6): 555-556, 1979

In vitro activity of aztreonam combined with tobramycin and gentamicin against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis. Antimicrobial Agents and ChemoTherapy 31(9): 1403-1405, 1987

In vitro activity of tobramycin and gentamicin against Enterobacteriaceae and gentamicin-resistant, carbenicillin-resistant Pseudomonas aeruginosa. Current Therapeutic Research, Clinical and Experimental 17(5): 488-496, 1975