EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Ultrastructural changes in the heart of rats treated with chloroquine


West African Journal of Pharmacology and Drug Research 4(1): 7-15
Ultrastructural changes in the heart of rats treated with chloroquine
Effects of prolonged chloroquine administration on ultrastructure of the heart was studied in albino rats. Chloroquine when administered orally (30-40 mg/kg/day) or subcutaneously (20 mg/kg/day) for two to four weeks, produced marked degenerative changes in the mitochondria and myofibrils of the myocardium. The mitochondria were more susceptible to the toxic effect of chloroquine than were other cell organelles. Moreover, the cytotoxic effect of the drug appeared to be related to total dose. Chloroquine-induced abnormalities were reversible on terminating medication. These results indicate that prolonged chloroquine administration impairs ultrastructure of the myocardium.

(PDF 0-2 workdays service: $29.90)

Accession: 006857201

PMID: 602194



Related references

Isolation and ultrastructural characterization of autophagic vacuoles from hepatocytes of chloroquine treated rats. Journal of Cell Biology 59(2 PT 2): 121, 1973

Lens opacities associated with lipidosis like ultrastructural alterations in rats treated with chloroquine chlorphentermine or iprindole. Experimental Eye Research 24(6): 621-632, 1977

Ultrastructural changes in retinal ganglia cells and retinal pigment epithelium of white rats treated with chloroquine. Meditsinskaya Parazitologiya i Parazitarnye Bolezni 50(4): 34-36, 1981

Chloroquine pharmacokinetics in tissues of pyrogen treated rats and implications for chloroquine related pruritus. Research Communications in Chemical Pathology and Pharmacology 30(3): 419-430, 1980

Ultrastructural findings in the heart of rats treated with carbon tetrachloride. Rivista di Patologia Clinica E Sperimentale 6(2): 181-187, 1965

Ultrastructural features of lymphocyte suppression induced by anthrax lethal toxin and treated with chloroquine. Laboratory Investigation; A Journal of Technical Methods and Pathology 87(2): 182-188, 2006

Effects of chloroquine on the adrenocortical function. I. Concentration of chloroquine and morphological changes in the suprarenal gland of rats on long-term administration of chloroquine. Zeitschrift für Rheumaforschung 32(7): 306-312, 1973

Effects of chloroquine on the adreno cortical function part 1 concentration of chloroquine and morphological changes in the adrenal gland of rats on long term administration of chloroquine. Zeitschrift fuer Rheumaforschung 32(7-8): 306-312, 1973

Histochemical and ultrastructural studies on acute toxicity of ketamine chlorhydrate. III. Ultrastructural aspects of the liver in rats treated with Ketalar. Minerva Anestesiologica 40(10): 475-484, 1974

Accelerated hemostasis in chloroquine treated rats. Thrombosis et Diathesis Haemorrhagica 34(2): 545-547, 1975