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Ultrastructural changes of the tegument syncytium vitelline cells and muscles of schistosoma japonicum caused by pyquiton






Acta Zoologica Sinica 27(4): 305-309

Ultrastructural changes of the tegument syncytium vitelline cells and muscles of schistosoma japonicum caused by pyquiton

Half an hour after administration of pyquiton to mice infected with S. japonicum at a single dose of 300 mg/kg, the transmission electromicroscopy of schistosomes removed from the animals showed some damage in the tegument, syncitium, vitelline cells and muscles. By 2-6 h after medication the ultrasructural changes in these tissues of the worms were more prominent. The main lesions of the tegument included swelling and rupture of cytoplasmic processes; emergence of large myelin-like, residual bodies, mitochondria, vacuoles and oval bodies of moderate electron density; decrease in rod-like, discoid and spherical secretary bodies as well as AKP [alkaline phosphatase] activities. By 0.5-24 h after administration, the syncitial and vitelline cells of the worms were markedly swollen, nuclear membranes had become indistinct with lysed chromatin nucleoli and granular endoplasmic reticulum had disappeared and mitochondria had degenerated. In the muscular system the circular muscle fibers of the worms were lysed, while the longitudinal fibers were swollen or became lysed 24 h later.


Accession: 006857495



Related references

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