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Ultrastructural cytochemistry of p n n di methylamino beta phenethylamine oxidation reactions activation and inhibition studies


Journal of Histochemistry and Cytochemistry 24(3): 540-555
Ultrastructural cytochemistry of p n n di methylamino beta phenethylamine oxidation reactions activation and inhibition studies
The oxidation of p-N,N-dimethylamino-.beta.-phenethylamine (DAPA) by amine oxidase(s) (AO), i.e., diamine oxidase (DAO), monoamine oxidase (MAO) and/or possibly other oxidases, has been previously demonstrated. This study reports the results of variations in fixation procedures and the incorporation of a series of possible activators and inhibitors into the DAPA oxidase (DAPAO) and DAPAO-BSPT [2-(2'-benzothiazolyl)-5-styryl-3-(4'-phthalhydrazidyl) tetrazolium chloride] reaction media in an attempt to elucidate the oxidase(s) involved. Results of these studies are indicative of at least 2 different oxidases acting preferentially on one or the other of the 2 systems. The presence of MAO, especially in unfixed tissue, and DAO, especially in fixed tissue, is denoted and that of other oxidase(s) is connoted. Guinea pig kidney was used in this study.


Accession: 006857837



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Ultrastructural cytochemistry of p-N,N-dimethylamino-beta-phenethylamine (DAPA) oxidation reactions. "activation" and inhibition studies. Journal of Histochemistry and Cytochemistry 24(3): 540-555, 1976

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