+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ultrastructural localization of actin in insulin containing granules



Ultrastructural localization of actin in insulin containing granules



Biology of the Cell 41(2): 157-160



Immunoreactive actin molecules were localized in insulin-containing granules by the protein A-gold immunocytochemical technique. The labeling was found at the periphery of the dense core or aligned over the limiting-membrane of the granules. The dual localization suggests that an association of actin molecules with the granule-limiting-membrane and the secretory product exists. Evidently contractile proteins are present in secretory granules and must play an important role in protein secretion.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006858773

Download citation: RISBibTeXText


Related references

Ultrastructural localization of insulin-like growth factor-2 to the secretory granules of insulin cells A study in normal and diabetic rats. Ultrastructural Pathology 21(5): 457-466, 1997

Localization of glycoproteins in insulin secretory granules by ultrastructural autoradiography. Journal of Histochemistry and Cytochemistry 35(10): 1059-1062, 1987

Ultrastructural localization of synaptophysin to the secretory granules of normal glucagon and insulin cells in human islets of Langerhans. Ultrastructural Pathology 15(3): 215-219, 1991

Ultrastructural localization of lactoferrin in the granules other than typical secondary granules of human neutrophils. Human Cell 6(1): 42-48, 1993

Ultrastructural localization of actin and actin-binding proteins in the nucleus. Histochemistry and Cell Biology 131(3): 425-434, 2009

Ultrastructural localization of human placental lactogen in distinctive granules in human term placenta: comparison with granules containing human chorionic gonadotropin. Journal of Histochemistry and Cytochemistry 36(2): 193-197, 1988

Interaction of insulin storage granules with f actin in vitro. Diabetologia 15(3): 241, 1978

Interaction between insulin-storage granules and F-actin in vitro. Biochemical Journal 178(2): 367-371, 1979

Possible roles of actin fibers in intracellular distribution of insulin granules. Diabetologia 42(Suppl. 1): A36, 1999

Ultrastructural localization of zinc and calcium within the granules of rat Paneth cells. Journal of Histochemistry and Cytochemistry 32(2): 139-145, 1984

Ultrastructural localization of a characteristic acid phosphatase in granules of rabbit basophils. Journal of Histochemistry and Cytochemistry 22(12): 1092-1104, 1974

Ultrastructural localization of secretion competent granules in permeabilized bovine platelets. Nishizuka, Y , M Endo And C Tanaka (Ed ) Advances in Second Messenger And Phosphoprotein Research, Vol 24 The Biology And Medicine Of Signal Transduction; 7th International Conference on Cyclic Nucleotides, Calcium And Protein Phosphorylation, Kobe, Japan, October 8-13, 1989 Xxxiii+750p Raven Press: New York, New York, Usa Illus 662, 1990

Ultrastructural and immunocytochemical studies on the cytoskeleton in the anterior pituitary of rats with special regard to the relationship between actin filaments and secretory granules. Cell & Tissue Research 258(1): 25-30, 1989

Myosin 5a and actin network interactions are important for recruitment of new insulin granules for exocytosis. Diabetologia 46(Suppl. 2): A163, 2003

Insulin granules may be translocated to a ready-releasable pool along the actin fiber in the cytoplasm. Japanese Journal of Pharmacology 79(Suppl. 1): 282P, 1999