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Ultrastructural localization of actin in insulin containing granules

Ultrastructural localization of actin in insulin containing granules

Biology of the Cell 41(2): 157-160

Immunoreactive actin molecules were localized in insulin-containing granules by the protein A-gold immunocytochemical technique. The labeling was found at the periphery of the dense core or aligned over the limiting-membrane of the granules. The dual localization suggests that an association of actin molecules with the granule-limiting-membrane and the secretory product exists. Evidently contractile proteins are present in secretory granules and must play an important role in protein secretion.

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Accession: 006858773

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