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Ultrastructural studies on choroidal vessels in streptozotocin diabetic and spontaneously hypertensive rats



Ultrastructural studies on choroidal vessels in streptozotocin diabetic and spontaneously hypertensive rats



Research Communications in Chemical Pathology & Pharmacology 29(2): 211-228



Seven spontaneously hypertensive rats (SHR) and 14 Wistar inbred Kyoto strain rats (WKR) were used. Seven WKR were made diabetic by a single i.v. injection of streptozotocin (50 mg/kg body wt); the 7 untreated WKR served as controls. The choroidal vessels of all rats were observed by EM after 12 mo. The choroidal capillaries of control rats showed focal accumulation of basement membrane (BM) in the subendothelial space. Two distinct types of BM lesions were noted: homogeneous thickening and sparse interlacing branches or ramifications of BM. Increased BM caused indentations in the vascular wall. In diabetic rats BM of capillaries, small arteries and small veins showed arabesque ramifications of BM which represented advanced forms of the sparse interlacing ramifications seen in normal controls. Contiguous lesions of ramified BM, separated by narrow cytoplasmic processes projecting from the endothelial cells, resembled a scalloped border. In hypertensive rats the arabesque ramifications were most conspicuous in the small veins. Homogeneous thickening of BM was noted in choroidal capillaries, small arteries and small veins of SHR, although ramified BM was seen adjacent to it. Endothelial cell proliferation was seen in the small arteries of diabetic and hypertensive rats. The cytoplasm of endothelial cells at the lesion of proliferation was broadened, and cell nuclei appeared cubic or spherical; the arterial lumina were narrowed. Complete occlusion was seldom seen in the choroidal arteries of diabetic rats but it was observed in small arteries of SHR, accompanied by hypertrophy of medial smooth muscle cells and endothelial proliferation. Basement membrane accumulation and endothelial proliferation were common to both groups of rats but the overall effect of pathological changes was more profound in hypertension than in diabetes.

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Accession: 006860131

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PMID: 7414045


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