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Uni variate and multi variate analysis of the laboratory data reflecting the clinical severity of ulcerative colitis

Uni variate and multi variate analysis of the laboratory data reflecting the clinical severity of ulcerative colitis

Fukuoka Acta Medica 75(2): 35-46

Total measurements (258) of 21 various laboratory examinations were carried out prior to, and at certain intervals after, medical treatment in 39 patients with ulcerative colitis to find out which laboratory tests are useful as indicators for the severity of this disease. The severity was classified into 4 grades according to clinical signs and symptoms such as diarrhea, rectal bleeding, fever and tachycardia. Correlation between the severity and other variables was analyzed using a stepwise multiple regression method. By univariate analysis, 17 of 21 variables showed a significant relation to the severity. By stepwise multiple regression analysis, only 5 variables were significantly correlated with clinical severity. They include .alpha.1-acid glycoprotein, prealbumin, lysozyme, leukocyte count, and complement C4. These 5 laboratory examinations, particularly .alpha.1-acid glycoprotein and prealbumin, are apparently useful and objective indicators for the severity of ulcerative colitis.

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Accession: 006866056

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PMID: 6735345

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