+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Unmasking of actual and potential receptor sites for cholera toxin in intestinal mucosal homogenates



Unmasking of actual and potential receptor sites for cholera toxin in intestinal mucosal homogenates



Journal of Infectious Diseases 139(2): 235-236



Endogenous and exogenous sialidases appear to unmask sialidase-stable and sialidase-labile gangliosides in [rabbit] intestinal mucosal homogenates by attacking glycoproteins. Exogenous (but not endogenous) sialidase then converts sialidase-labile gangliosides into the cholera toxin-binding, sialidase-stable ganglioside GM1 (galactosyl-N-acetylgalactosaminyl [sialosyl] lactosyl ceramide). Since Vibrio cholerae produces sialidase, these observations may be relevant to the course of cholera.

(PDF emailed within 0-6 h: $19.90)

Accession: 006867084

Download citation: RISBibTeXText

PMID: 438537

DOI: 10.1093/infdis/139.2.235


Related references

Radiolabeled toxin for studying binding of cholera toxin and toxoids to intestinal mucosal receptor sites. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 145(4): 1187-1191, 1974

The adjuvant effect of cholera toxin cholera toxin b subunit and glutaraldehyde modified cholera toxin on the mucosal immune response of rabbits to 2 acetylaminofluorene thyroglobulin conjugates. FASEB Journal 4(3): A500, 1990

Changes in intestinal fluid and mucosal immune responses to cholera toxin in Giardia muris infection and binding of cholera toxin to Giardia muris trophozoites. Infection and Immunity 50(1): 243-249, 1985

Human intestinal epithelial cells, not intestinal fibroblasts, secrete pro-inflammatory cytokines in response to mucosal adjuvants cholera toxin and IL-1-beta in vitro. Abstracts of the General Meeting of the American Society for Microbiology 101: 330-331, 2001

Binding of cholera entero toxin to hamster intestinal mucosal membranes. Clinical Research 26(5): 704A, 1978

In vivo analysis of the effect of cholera toxin on the activation of antigen-specific T lymphocytes at mucosal sites. Helicobacter 8(4): 411, 2003

The effect of cholera toxin and cholera toxin B subunit on the nasal mucosal membrane. Vaccine 9(11): 825-832, 1991

Characterization of the receptor for cholera toxin and Escherichia coli heat-labile toxin in rabbit intestinal brush borders. Biochemical Journal 238(2): 313-322, 1986

Failure to reverse cholera toxin induced intestinal secretion by agents which decrease mucosal cyclic amp. Canadian Journal of Physiology & Pharmacology 57(9): 1004-1010, 1979

Failure to reverse cholera toxin induced intestinal secretion by agents which decrease mucosal cAMP. Canadian Journal of Physiology and Pharmacology 57(9): 1004-1010, 1979

Immunocytochemical study on cholera toxin binding sites by monoclonal anti-cholera toxin antibody in neuronal tissue culture. Brain Research 242(2): 233-241, 1982

Efficacy of intraduodenal, oral and parenteral boosting in inducing intestinal mucosal immunity to cholera toxin in rats. Immunological Investigations 28(5-6): 339-346, 1999

Identification of cholera toxin-binding sites in the nucleus of intestinal epithelial cells. Febs Letters 242(2): 309-313, 1989

Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA. Immunology Letters 97(2): 181-188, 2005

Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA. Expert Review of Vaccines 2(2): 205-217, 2003