Section 7
Chapter 6,868

Unscheduled thio phosphamide induced synthesis in human lymphocytes

Titenko, N.V.

Tsitologiya i Genetika 17(2): 58-62, 76


Accession: 006867468

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An unscheduled DNA synthesis in human nonreplicative lymphocytes is shown to follow cell exposure to thiophosphamide at a dose level of 1-10 .mu.g/ml. Incorporation of 3H-thymidine in the absence of the mutagen is probably due to spontaneous reparative processes. Significant variations are found of spontaneous and thiophosphamide-induced levels of a reparative DNA synthesis in normal individuals.