Unscheduled thio phosphamide induced synthesis in human lymphocytes

Titenko, N.V.; Titenko, N.V

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Unscheduled thio phosphamide induced synthesis in human lymphocytes

Titenko, N.V.

Tsitologiya i Genetika 17(2): 58-62, 76

1983

Accession: 006867468

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An unscheduled DNA synthesis in human nonreplicative lymphocytes is shown to follow cell exposure to thiophosphamide at a dose level of 1-10 .mu.g/ml. Incorporation of 3H-thymidine in the absence of the mutagen is probably due to spontaneous reparative processes. Significant variations are found of spontaneous and thiophosphamide-induced levels of a reparative DNA synthesis in normal individuals.

Related References

Kagramanyan, M.S. 1981: Thio phosphamide induced sister chromatid exchanges in unstimulated human lymphocytes under various storage conditions Biologicheskii Zhurnal Armenii 34(9): 897-902

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Celotti, L.; Ferraro, P.; Biasin, M.R. 1992: Detection by fluorescence analysis of DNA unwinding and unscheduled DNA synthesis, of DNA damage and repair induced in vitro by direct-acting mutagens on human lymphocytes Mutation Research 281(1): 17-23