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Use of acridine yperite in selection of actinomyces nodosus producing amphotericin b



Use of acridine yperite in selection of actinomyces nodosus producing amphotericin b



Antibiotiki (Moscow) 24(1): 3-6



The effect of acridine-yperite (AY) on [Streptomyces] nodosus LIA 0861 at various physiological stages of development was studied. The spores and the vegetative cells were sensitive to AY. The level of the mutagen effect depended on the exposure time and the physiological state of the A. nodosus cells during the treatment. The treatment of the spore suspension with AY had an insignificant effect on the strain morphological variation, while the number of the morphologically changed colonies markedly decreased when 5-h vegetative cells were subjected to the mutagen effect. A decrease in the average antibiotic activity of A. nodosus was observed when its spores were subjected to the treatment with AY, which was associated with a decrease in the number of the plus variants. The treatment of 5-h vegetative cells increased the average antibiotic activity of the culture which correlated with an increase in the number of the plus variants.

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Accession: 006876302

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