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Use of pseudoisochromatic plates in the diagnosis of ethambutol induced toxic optic neuropathy

Use of pseudoisochromatic plates in the diagnosis of ethambutol induced toxic optic neuropathy

Rinsho Ganka 38(12): 1229-1233

Standard Pseudoisochromatic Plates Part 2 for Acquired Color Vision Defects (SPP-2) were used for the detection and evaluation of color vision disturbance in optic neuropathy due to ethambutol therapy. A series of 47 patients under systemic ethambutol treatment was examined using SPP-2, AO-HRR plates and Farnsworth's dichtomous test. Optic neuropathy was suspected in 11 patients, all of whom were more or less color-defective. Red-green defect was more marked than blue-yellow in mild cases. Both types of defects were involved equally in severe cases and resulted in achromatopsia. While test results with SPP-2 failed to indicate the severity of defects due to individual differences, the number of errors was fairly well correlated with the visual acuity. Apparently, color vision tests are useful in the routine screening for optic neuropathy in patients undergoing systemic ethambutol therapy. Pseudoisochromatic plates are preferred for this procedure. For acquired vision defects, SPP-2 is currently the only pseudoisochromatic plates available.

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Accession: 006881050

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