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Uv induced tandem double mutations in the trpa gene of escherichia coli



Uv induced tandem double mutations in the trpa gene of escherichia coli



Studia Biophysica 80(3): 231-232



The UV light induction of tandem double mutations in a reverse mutation system was shown using trpA mutants which are characterized by the codon sequences GAA and AAG in codon position 211. Among 597 Trp+ independent revertants of the trpA (AAG211) strain 3 full revertants were detected arising from UV-induced tandem double base exchanges. In the codon unit 211 full revertants due to single base exchanges are at least 20 times as frequent as full revertants due to tandem double base exchanges.

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