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Vaccination experiments against transmissible gastro enteritis of swine 7. immuno globulin characteristics of antibodies in milk of sows vaccinated with the ck p strain of transmissible gastroenteritis virus



Vaccination experiments against transmissible gastro enteritis of swine 7. immuno globulin characteristics of antibodies in milk of sows vaccinated with the ck p strain of transmissible gastroenteritis virus



Acta Veterinaria Academiae Scientiarum Hungaricae 28(2): 131-144



The dynamics of specific TGE [transmissible gastroenteritis] VN [virus-neutralizing] antibodies were followed up during lactation in the sera and milk wheys of sows vaccinated orally or i.m. with the CKp strain of TGE virus and of sows recovered from TGE. The Ig [immunoglobulin] classes of lactogenic TGE antibodies and their specific VN activity were determined. The average VN antibody titer was higher by 1 ln unit in the colostral wheys of orally vaccinated or naturally infected sows than in their serum samples taken at the time of farrowing. Between days 3-7 post-farrowing, the VN titer of milk wheys fell to a level of 2-3 ln units lower than that of blood sera. Thereafter, the titers remained practically constant up to the end of lactation. Following i.m. vaccinations, the mean VN antibody titer was higher in both the blood sera and colostral wheys than in those of orally vaccinated or naturally infected sows. From the 1st day of lactation, the antibody titers declined markedly in milk of i.m. vaccinated sows and disappeared between days 7-14 post-farrowing. In orally vaccinated sows, the specific VN activity of lactogenic TGE antibodies was associated primarily with IgA just as in sows recovered from TGE. In orally vaccinated and naturally infected sows' milk, the titer decline of 2-3 ln units, compared to the serum titer, originated mainly from the marked fall in IgG concentration between days 2-7 post-farrowing and from the decreasing VN activity of this Ig class. The VN activity persisted at a constant level from that time on until the end of lactation and was primarily, if not solely, associated with the specific TGE VN activity of secretory IgA, the concentration of which remained constant between the 4th day post-farrowing and the end of the lactation period. In the i.m. vaccinated sows, as a result of parenteral antigenic stimulation, lactogenic TGE antibodies appeared to be primarily, if not solely, of the IgG class. Consequently, antibody levels in milk fell rapidly, parallel with the concentration decline of IgG. Depending on its initial level, the specific VN activity of milk disappeared between days 7-14 post-farrowing, i.e., the time when the IgG concentration in the milk whey fell under a certain level.

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