Variability of iron and copper serum concentrations and values of blood and marrow hematologic determinations in acute leukemia in children
Folia Medica Cracoviensia 20(3): 389-398
Serum Fe and Cu were studied in 57 children with acute lymphoblastic leukemia. Serum Fe and Cu determinations (314) were performed using atomic absorption spectrophotometry. The highest Fe (171.2 .mu.g%) and Cu (262.7 .mu.g%) values were obtained at the beginning of the disease. Efficient treatment decreased Fe and Cu concentrations to normal values. Significant serum Cu increased in hematologic remission was observed in extra-marrow disease location (163.8 .mu.g%) in remission complicating infections (147.6 .mu.g%) and in the group of children in whom the disease recurred after 1/2-2 mo. (168.8 .mu.g%).