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Whole body auto radiographic studies on the distribution of radioactive carbon from carbon 14 labeled glucose in carbon mon oxide poisoned mice



Whole body auto radiographic studies on the distribution of radioactive carbon from carbon 14 labeled glucose in carbon mon oxide poisoned mice



Acta Histochemica et Cytochemica 12(3): 219-229



Changes in the distribution of radioactive carbon from [U-14C]glucose in mice with CO were studied by whole-body autoradiography. Two periods could be distinguished in the changes of 14C concentrations in organs affected by CO poisoning with prolonged exposure time up to 6 h: the 1st stage of 30 and 60 min and the 2nd stage of over 1 h. In the 1st stage, a marked decrease in 14C concentration was shown for the brain, palatine, submaxillary and Harder's gland, while an increase was shown for the myocardium, liver, kidney cortex and blood. In the 2nd stage, changes of 14C concentration in organs were less pronounced and showed a trend for almost all organs resembling that of blood.

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