Section 7
Chapter 6,924

Yeast phenylalanyl transfer rna synthetase evidence for the formation of adp by phosphorolysis of enzyme bound aminoacyladenylate

Guedon, G.; Ebel J P.; Remy, P.

Biochimie 69(11-12): 1175-1182


ISSN/ISBN: 0300-9084
Accession: 006923967

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ADP and Ap3A are synthesized by the yeast phenylalanyl-tRNA synthetase, according to reaction pathways similar to the pyrophosphorolysis of the intermediate aminoacyladenylate or to the one leading to Ap4A synthesis. The enzyme-bound phenylalanyladenylate reacts with inorganic phophate or ADP to yield, respectively, ADP or Ap3A. The rate of synthesis is strongly stimulated by Zn2+. This new phosphorolysis activity accounts for the complex pattern of bisnucleoside polyphosphate syntheses starting from ATP.

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