+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

A case of early gastric cancer producing alpha fetoprotein associated with gastric anisakiasis

A case of early gastric cancer producing alpha fetoprotein associated with gastric anisakiasis

Gastroenterological Endoscopy 34(3): 576-580

A 41-year-old man was admitted to our hospital because of gastric cancer. X-ray and endoscopic examination revealed a protruded lesion with irregular surface and central depression on the lesser curvature of the upper body (Figure 1, 2). Except for a slightly high 23 ng/ml serum AFP, no abnormal findings were noted on blood biochemistry, abdominal ultrasonography and computed tomography. Total gastrectomy was carried out and no liver metastasis were found. AFP level became to normal range (5 ng/ml) after operation. On the resected specimen, a Borrmann type 2 like protruded lesion measuring 2.8.times. 2.8 cm was noted on the anterior aspect of the lesser curvature of the upper body (Figure 3). Histological findings in the gastric cancer showed papillary clear adenocarcinoma mixed with hepatoid carcinoma and massive invasion to the submucosal layer (Figure 4, 5). Lymph nodes metastasis were noted. Eosinophilic granuloma which was formed by the infestation of a laval anisakis was found in the gastric mucosa of the posterior wall (Figure 6). The localization of AFP with ABC method was immunohistochemically demonstrated in the cytoplasm of the primary lesion and the metastatic lesions of the regional lymph nodes (Figures 7). Early gastric cancer producing AFP is rare. Only 6 reported cases of early gastric cancer with immunohistochemical localization of AFP in which a preoperative serum AFP level of more than 20 ng/ml became normal after gastrectomy were reviewed in Japan (Table 1).

(PDF emailed within 1 workday: $29.90)

Accession: 006932382

Download citation: RISBibTeXText

Related references

A rare case of alpha-fetoprotein-producing early gastric cancer. Hepato-Gastroenterology 48(39): 687-691, 2001

Alpha-fetoprotein producing early gastric cancer Report of a case. Stomach & Intestine 28(2): 203-207, 1993

Early type i gastric cancer producing alpha fetoprotein report of a case. Gastroenterological Endoscopy 27(4): 513-522, 1985

Alpha-fetoprotein-producing early gastric cancer of the remnant stomach: report of a case. Surgery Today 37(11): 995-999, 2007

Resection of liver metastasis from alpha-fetoprotein-producing early gastric cancer: Report of a case. Surgery Today 27(6): 563-566, 1997

Alpha-fetoprotein-producing early gastric cancer accompanying liver cirrhosis: a case report. Journal of Gastroenterology 29(1): 66-70, 1994

Successfully treated metachronous liver metastasis of alpha-fetoprotein-producing early gastric cancer: case report. Hepato-Gastroenterology 51(57): 919-920, 2004

A case of IgA-lambda producing gastric plasmacytoma associated with alpha-fetoprotein producing gastric carcinoma. Nihon Shokakibyo Gakkai Zasshi 83(8): 1524-1529, 1986

A case of alpha-fetoprotein-producing gastric cancer. Annals of the Academy of Medicine, Singapore 30(1): 58-61, 2001

Alpha-fetoprotein-producing early gastric cancer: report of two cases. Kurume Medical Journal 50(1-2): 63-66, 2003

Alpha-fetoprotein-producing gastric cancer: report of one case. Di 1 Jun Yi Da Xue Xue Bao 24(3): 299, 2004

A case of alpha-fetoprotein-producing minute mucosal gastric cancer. Nihon Shokakibyo Gakkai Zasshi 104(7): 1051-1056, 2007

Seronegative alpha-fetoprotein-producing gastric cancer: an early form of aggressive cancer. Internal Medicine 43(10): 889-890, 2004

Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation. World Journal of Gastroenterology 22(36): 8203-8210, 2017

alpha Fetoprotein producing early gastric cancer with liver metastasis: report of three cases. Gut 32(5): 542-545, 1991