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A case of insulin dependent diabetes mellitus with insulitis

A case of insulin dependent diabetes mellitus with insulitis

Journal of the Japan Diabetes Society 34(8): 725-730

A 29-year-old male was admitted to our hospital with hyperglycemia (800 mg/dl) and hyperamylasemia (5080 IU/ml). He died one hour after admission and autopsy was performed. The pancreas weighed 100 gm. Neither reduction in the number of pancreatic islets nor atrophy of the islet were found, but scattered and sparse lymphocytic infiltration was seen in the islets (insulitis). Lymphocytic infiltration was seen in the exocrine gland and parotid gland. Histochemical staining demonstrated normal glucagon and somatostatin containing cells but no insulin-staining cells. These findings are similar to those of islet-cell lesions in mice with diabetes induced by EMC-virus diabetic strain. The majority of infiltrated lymphocytes were Leu 7-positive cells plus a few Leu M1-positive cells. This case was regarded as IDDM which had developed abruptly due to destruction of both endocrine and exocrine pancreatic tissue. This is a useful case for understanding the pathogenesis of insulin-dependent diabetes mellitus in Japanese patients and also for clarifying the significance of hyperamylasemia in IDDM.

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Accession: 006932636

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