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A model for the appearance of stochastic pores in membranes due to self oscillations

A model for the appearance of stochastic pores in membranes due to self oscillations

Bioelectrochemistry & Bioenergetics 25(1): 91-104

The aim of this paper is to demonstrate the possibility of the appearance of stochastic pores in membranes, irrespective of external reasons. Fluctuations in thickness, due to structural inhomogeneities and the dynamics of amphiphile molecules, can determine the perforation of a membrane equivalent to the appearance of a pore. The height of the energy barrier for membrane perforation (pore formation) is equal to 91 kT. The geometric profile is of an elliptical toroidal form. Generally, after membrane perforation, the pore evolves to a stable state. Other possibilities are also discussed.

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Accession: 006947923

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