+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Accelerated passive Heymann nephritis in rats as an experimental model for membranous glomerulonephritis and effects of azathioprine and prednisolone on the nephritis

Accelerated passive Heymann nephritis in rats as an experimental model for membranous glomerulonephritis and effects of azathioprine and prednisolone on the nephritis

Japanese Journal of Pharmacology 49(1): 101-110

Progressive passive Heymann nephritis (group II) was induced in rats by i.v. injections of rabbit antiserum against an antigen from the brush border of the proximal tubules of rat kidney following immunization with rabbit .gamma.-globulin in Freund's complete adjuvent, and the process of the disease was compared with that of rats that received the antiserum alone (group I). The rats of group I showed proteinuria (30-50 mg/day) and plasma cholesterol content (80-90 mg/dl) slightly higher than the normal level from the 17th or the 22nd day after antiserum injection to the 90th day. The rats of group II revealed a heavy proteinuria (300-400 mg/day) and hypercholesterolemia (approx. 200 mg/dl) during the same period. In group II, there were the thickening of glomerular basement membrane (GBM) and spike formation. Moreover, granular deposits of rat IgG, rabbit IgG and rat C3 were observed along the GBM. These changes were weaker in group I. When given orally, daily, azathioprine (20 mg/kg) and prednisolone (1 and 3 mg/kg) showed a beneficial effect on the nephritis in group II. The group II model closely resembles human glomerulonephropathy and may be useful for studying the effect of medication on glomerulonephropathy.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 006977575

Download citation: RISBibTeXText

PMID: 2724671

DOI: 10.1254/jjp.49.101

Related references

Effects of cyclosporin A on experimental nephritis in rats (2): Cyclosporin A suppresses the development of accelerated passive Heymann nephritis. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 103(1): 19-26, 1994

Molecular analysis of experimental membranous glomerulonephritis (Heymann nephritis). Verhandlungen der Deutschen Gesellschaft für Pathologie 80: 139-147, 1996

Heymann nephritis revisited--new insights into the pathogenesis of experimental membranous glomerulonephritis. Clinical and Experimental Immunology 94(3): 393-394, 1993

The cell biology of Heymann nephritis: a model of human membranous glomerulonephritis. American Journal of Kidney Diseases 10(1): 74-76, 1987

Studies on antinephritic effect of TJ-8014, a new Japanese herbal medicine (4): Effects on accelerated passive Heymann nephritis in rats. Japanese Journal of Pharmacology 54(3): 265-275, 1990

Pathogenic mechanism of membranous glomerulonephritis obtained from Heymann nephritis and human membranous glomerulonephritis. Nihon Jinzo Gakkai Shi 53(5): 672-676, 2011

Detection of glomerular antigens in experimental nephritis (passive Heymann nephritis, serum sickness, and Masugi nephritis)--focal glomerular desensitization and the immuno-deposition elution test. Nihon Jinzo Gakkai Shi 25(8): 961-981, 1983

Experimental studies on membranous nephropathy. (II) Role of complement system in proteinuria of passive Heymann nephritis. Nihon Jinzo Gakkai Shi 26(3): 301-307, 1984

Passive Heymann's nephritis as a model of immune glomerulonephritis mediated by antibodies to immunoglobulins. Clinical and Experimental Immunology 41(2): 189-195, 1980

Monocyte involvement in experimental immune complex nephritis passive heymann nephritis. Experimental Cell Biology 57(2): 98, 1989

Differential capacity of anti-RAP and anti-megalin antibodies to produce progressive passive Heymann nephritis - implications for the pathogenesis of idiopathic human membranous glomerulonephritis. Journal of Pathology 210(3): 282-287, 2006

Antiproteinuric effect of KD3-671, an angiotensin II type 1 receptor antagonist, in rats with accelerated passive Heymann nephritis. Japanese Journal of Pharmacology 88(2): 213-216, 2002

Beneficial effects of 5-lipoxygenase activating protein inhibition in accelerated nephrotoxic serum nephritis and passive Heymanns nephritis in rats. Journal Of The American Society Of Nephrology. 10(program And Abstr. Issue): 533a,., 1999

The effects of azathioprine and prednisolone on T- and B-lymphocytes in patients with lupus nephritis and chronic glomerulonephritis. Clinical Nephrology 14(5): 233-237, 1980

Sequential therapy for diffuse proliferative and membranous lupus nephritis: cyclophosphamide and prednisolone followed by azathioprine and prednisolone. Nephron 71(3): 321-327, 1995