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Action of estradiol on muellerian duct regression induced by treatment with norethindrone of female chick embryos



Action of estradiol on muellerian duct regression induced by treatment with norethindrone of female chick embryos



General & Comparative Endocrinology 80(1): 101-106



Treatment of genetically female chick embryos with norethindrone (NET), a progesterone-like steroid chemically related to testosterone, caused two types of Muellerian duct (MD) deficiencies. The first consisted in an absence of the caudal part of the ducts owing to their partial agenesia occurring between Days 5 and 7 of embryonic life. This is nonspecific since it was observed after a treatment with almost all steroidal sex hormones. In particular, this was obtained with estradiol which also increases the frequency and extent of agenesia caused by the NET, as reported here. The second type of deficiency appeared between Days 12 and 14 and was due to a regression destroying the more or less large part of the MDs having escaped agenesia, i.e., for most of the cephalic half. This resulted from the influence of the anti-Muellerian hormone originating from the ovary and normally inhibited by the ovarian estrogens. This protective action of ovary and normally inhibited by the NET, but an additional treatment with estradiol removed this inhibition and prevented duct regression. Our results suggest that estrogen protects the duct from the regression induced indirectly by NET, by acting both at gonad and MD levels.

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Accession: 006981214

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PMID: 2272472


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