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Activity of myrtocyan an anthocyanoside complex from vaccinium myrtillus vma on platelet aggregation and adhesiveness

Activity of myrtocyan an anthocyanoside complex from vaccinium myrtillus vma on platelet aggregation and adhesiveness

Fitoterapia 61(1): 13-22

The effects of Myrtocyan, an anthocyanoside complex from V. myrtillus (VMA), on platelet functions have been investigated in vitro and in vivo, in comparison with acetylsalicylic acid, dipyridamole and ticlopidine hydrochloride. When tested in vitro in rabbit platelet-rich plasma, VMA inhibited platelet aggregation induced by ADP, collagen and sodium arachidonate in a concentration related manner. VMA retained its activity when tested in rabbit gel-filtered platelets. VMA has also proved to be active in inhibiting ADP-induced platelet aggregation in rat circulating blood. In vivo, VMA orally administered at doses ranging from 5 to 400 mg/kg prolonged template bleeding time in rats; its effect lasted for 24 hours. At the highest dose tested it had no effects on hematocrit and on intrinsic, extrinsic and common pathways of blood coagulation. Single oral doses of VMA (400 mg/kg) reduced the adhesiveness of mouse platelets to glass beads. To further characterize the activity of VMA, the effects on platelet aggregation of three of the main anthocyanosides in the extract were studied in vitro. Cyanidin 3-O-glucoside, delphinidin 3-O-glucoside and malvidin 3-O-glucoside when tested in rabbit platelet-rich plasma inhibited platelet aggregation induced by ADP, collagen and sodium arachidonate. We conclude that the anti-platelet activity shown by VMA must be due, to a large extent, to its antocyanoside constituents.

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Accession: 006984109

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