EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Administration of triazolam prior to recovery sleep effects on sleep architecture subsequent alertness and performance



Administration of triazolam prior to recovery sleep effects on sleep architecture subsequent alertness and performance



Psychopharmacology 99(4): 526-531



The effects of triazolam (0.125, 0.25, and 0.5 mg) versus placebo on recovery sleep staging, subsequent alertness and psychomotor performance were evaluated in humans. Forty-five healthy male subjects were deprived of sleep for 24 h, then administered a single dose of triazolam or placebo using a double-blind procedure. Subjects than attempted to obtain recovery sleep under non-sleep-conducive conditions (sitting upright in a well-lit, crowded chamber) for the next 6 h, followed by 18 more hours of sleep deprivation. During all sleep deprivation periods subjects were tested bihourly on a performance assessment battery which included symbol digit modalities tests (SDMT), four-letter search (FLS), logical reasoning (LR), time estimation (TE), visual vigliance (VV), and short term memory (STM) tasks. Sleepiness levels were measured objectively with multiple sleep latency tests (MSLT) and subjectively with the Stanford Sleepiness Scale (SSS). Compared to placebo, all doses of triazolem resulted in increased amounts of stage 3-4 sleep, and the 0.5 mg dose significantly reduced awakenings (Ps < 0.05). Although subjects receiving triazolam averaged 21-42 min more total sleep time (TST) than subjects receiving placebo, differences in TST were not statistically significant. Apparent triazolam-mediated benefits to sleep quality resulted in no obvious improvements in performance or alertness levels during subsequent sleep deprivation. It was concluded that the increases in stage 3-4 sleep amounts were most likely due to triazolam-mediated increases arousal thresholds, and the triazolam mediated changes in sleep parameters obtained in the present study were not indicative of substantial changes in the recuperative value of sleep.

(PDF emailed within 0-6 h: $19.90)

Accession: 006989565

Download citation: RISBibTeXText

PMID: 2594919

DOI: 10.1007/bf00589903



Related references

Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep. Journal of Psychopharmacology 26(8): 1047-1057, 2012

The Acute Effects of Intermittent Light Exposure in the Evening on Alertness and Subsequent Sleep Architecture. International Journal of Environmental Research and Public Health 15(3): -, 2018

Sleep homeostasis in suprachiasmatic nuclei-lesioned rats: effects of sleep deprivation and triazolam administration. Brain Research 589(2): 253-261, 1992

Mood, alertness, and performance in response to sleep deprivation and recovery sleep in experienced shiftworkers versus non-shiftworkers. Chronobiology International 29(5): 537-548, 2012

Maintenance of alertness and performance by a brief nap after lunch under prior sleep deficit. Sleep 23(6): 813-819, 2000

Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: A sleep dose-response study. Journal of Sleep Research 12(1): 1-12, March, 2003

Triazolam-induced sleep in the rat: influence of prior sleep, circadian time, and light/dark cycles. Psychopharmacology 105(3): 374-380, 1991

The impact of shift starting time on sleep duration, sleep quality, and alertness prior to injury in the People's Republic of China. Chronobiology International 31(10): 1201-1208, 2015

Triazolam as a hypnotic for geriatric patients. A double-blind cross-over comparison of nitrazepam and triazolam regarding effects on sleep and psychomotor performance. Acta Psychiatrica Scandinavica 67(5): 290-296, 1983

Effects of zopiclone, flunitrazepam, triazolam and levomepromazine on the triazolam and levomepromazine on the transient change in sleep-wake schedule: Polygraphic study, and the evaluation of sleep and daytime condition. Progress in Neuro-Psychopharmacology & Biological Psychiatry 17(2): 229-239, 1993

Effect of driving duration and partial sleep deprivation on subsequent alertness and performance of car drivers. Physiology & Behavior 84(5): 715-724, 2005

Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction. Brain, Behavior, and Immunity 25(1): 16-24, 2011

Sleep inertia following triazolam induced recovery sleep. Human Psychopharmacology 4(4): 291-296, 1989

Sleep inertia following triazolam-induced recovery sleep. Human Psychopharmacology: Clinical and Experimental 4(4): 291-296, 1989

Recovery sleep does not mitigate the effects of prior sleep loss on paclitaxel-induced mechanical hypersensitivity in Sprague-Dawley rats. Biological Research for Nursing 17(2): 207-213, 2015