Aggregation and orientation of human red blood cells in whole blood and blood suspensions treated with diamide and glutaraldehyde

Baeumler, H.; Distler, J.; Distler, B.; Lerche, D.; Hessel, E.; Meier, W.

Studia Biophysica 131(1-2): 125-132


Accession: 006994409

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The aggregation kinetics, the stationary aggregation behaviour as well as the orientation of human red blood cells (RBC) in saline solutions containing dextran (Dx) or fibrinogen and in plasma were investigated in a Couette system by means of a light back scattering technique. The aggregation of RBC as well as the orientation rate are reduced after treating the RBC with diamid or with glutaraldehyde of several concentrations. The orientation rate of RBC decreases with rising aggregability of RBC. Non-aggregating RBC suspensions show the highest orientability, strongly aggregating RBC suspensions (4 g/dl Dx70) the lowest one. These differences also remain after diamid and after glutaraldehyde treatment of RBC. It is concluded from the dependence of the orientability on the aggregability found in whole blood that the RBC aggregation can influence the microcirculation also due to alterations of orientability of RBC.