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Alpha antitrypsin alpha 1 proteinase inhibitor concentration in the patients with neoplastic disease

Alpha antitrypsin alpha 1 proteinase inhibitor concentration in the patients with neoplastic disease

Materia Medica Polona 20(3): 180-183

.alpha.1-Antitrypsin concentration was assayed in serum of 192 patients with neoplasma. Among all the clinically documented cases, the highest .alpha.1AAT concentration was found in the cancer of: lung (mean level - 765 .+-. 178 mg/dl), lower respiratory tract (737 .+-. 165 mg/dl), stomach (662 .+-. 155 mg/dl), liver (605 .+-. 182 mg/dl), ovary (586 .+-. 129 mg/dl), gall bladder (575 .+-. 107 mg/dl), esophagus (552 .+-. 147 mg/dl), pancreas - (552 .+-. 175 mg/dl), .alpha.1 AT concentration being increased in 100% of the cases examined. Lower incidence of elevated .alpha.1AT, 90% of the cases, was observed in hepatosplenomegaly and nasopharynx cancer, and 75-70%, in myeloma and in the cancer of colon, prostate and bladder. In breast carcinoma, only 50% of the cases the .alpha.1AT values were higher than normal. It seems that determination of .alpha.1AT can be taken advantage of in differential diagnosis, .alpha.1AT serving as one of the markers of neoplastic activity.

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Accession: 006999105

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PMID: 3266649

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