+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Alpha antitrypsin alpha 1 proteinase inhibitor concentration in the patients with neoplastic disease



Alpha antitrypsin alpha 1 proteinase inhibitor concentration in the patients with neoplastic disease



Materia Medica Polona 20(3): 180-183



.alpha.1-Antitrypsin concentration was assayed in serum of 192 patients with neoplasma. Among all the clinically documented cases, the highest .alpha.1AAT concentration was found in the cancer of: lung (mean level - 765 .+-. 178 mg/dl), lower respiratory tract (737 .+-. 165 mg/dl), stomach (662 .+-. 155 mg/dl), liver (605 .+-. 182 mg/dl), ovary (586 .+-. 129 mg/dl), gall bladder (575 .+-. 107 mg/dl), esophagus (552 .+-. 147 mg/dl), pancreas - (552 .+-. 175 mg/dl), .alpha.1 AT concentration being increased in 100% of the cases examined. Lower incidence of elevated .alpha.1AT, 90% of the cases, was observed in hepatosplenomegaly and nasopharynx cancer, and 75-70%, in myeloma and in the cancer of colon, prostate and bladder. In breast carcinoma, only 50% of the cases the .alpha.1AT values were higher than normal. It seems that determination of .alpha.1AT can be taken advantage of in differential diagnosis, .alpha.1AT serving as one of the markers of neoplastic activity.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006999105

Download citation: RISBibTeXText

PMID: 3266649


Related references

Multiple functions of alpha 1-antitrypsin and alpha 1-antichymotrypsin. 1. Role of lung epithelial cells in the proteinase-proteinase inhibitor balance. Monaldi Archives for Chest Disease 51(5): 424-425, 1996

Relationship between antiplasmin capacity and concentration of alpha 2-plasmin inhibitor, alpha 2-macroglobulin, alpha 1-antitrypsin, antithrombin III or C1-inactivator in plasma of patients with transient ischemic attacks. Rinsho Byori. Japanese Journal of Clinical Pathology 28(3): 261-264, 1980

Bioequivalence of a Liquid Formulation of Alpha 1 -Proteinase Inhibitor Compared with Prolastin®-C (Lyophilized Alpha 1 -PI) in Alpha 1 -Antitrypsin Deficiency. Copd 14(6): 590-596, 2017

Inhibition of human tissue (urinary) kallikrein by sera of patients suffering from hereditary alpha 1-antitrypsin (alpha 1-proteinase inhibitor) deficiency. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 362(7): 1013-1015, 1981

Increased proteolytic cleavage of alpha 1-antitrypsin (alpha 1-proteinase inhibitor) in knee-joint synovial fluid from patients with rheumatoid arthritis. Biochemical Society Transactions 18(5): 898-899, 1990

Serum concentration of alpha-2-macroglobulin, alpha-1-antitrypsin and alpha-2-antichymotrypsin in patients with Hodgkin's disease. Materia Medica Polona 24(1): 28-30, 1992

Dynamics of proteolysis inhibitor concentration (alpha 1-antitrypsin and alpha 2-macroglobulins) and proteolytic activity in the blood of burn patients. Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia .(2): 27-30, 1980

Concentration of protease inhibitor alpha 1-antitrypsin in the blood of patients with inflammatory periodontal disease. Zobozdravstveni Vestnik 40(1-5): 71-74, 1985

In vivo metabolism of inter-alpha-trypsin inhibitor and its proteinase complexes: evidence for proteinase transfer to alpha 2-macroglobulin and alpha 1-proteinase inhibitor. Archives of Biochemistry and Biophysics 248(2): 587-596, 1986

Modification of the isoinhibitors of human serum alpha 1-proteinase inhibitor (alpha 1-antitrypsin) by pancreatic proteases. Biological Chemistry Hoppe-Seyler 368(1): 77-84, 1987

Corneal synthesis of alpha-1-proteinase inhibitor (alpha-1-antitrypsin). Investigative Ophthalmology and Visual Science 35(2): 458-462, 1994

Long-term clinical outcomes following treatment with alpha 1-proteinase inhibitor for COPD associated with alpha-1 antitrypsin deficiency: a look at the evidence. Respiratory Research 18(1): 105, 2017

Alpha 1-proteinase inhibitor for alpha 1-antitrypsin deficiency. Medical Letter on Drugs and Therapeutics 30(761): 29-30, 1988

Concentration of some proteinase inhibitors: alpha 1-antitrypsin and alpha 2-macroglobulin in rabbit blood serum in two models of experimental atherosclerosis. Acta Biochimica Polonica 37(1): 125-127, 1990

Decreased functional activity of alpha 1 proteinase inhibitor and increased levels of alpha 1 proteinase inhibitor leukocyte elastase complex in bronchoalveolar lavage fluids from patients with pulmonary emphysema. American Review of Respiratory Disease 135(4 Part 2): A147, 1987