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Antigravity suit inflation: kidney function and cardiovascular and hormonal responses in men

Antigravity suit inflation: kidney function and cardiovascular and hormonal responses in men

Journal of Applied Physiology 66(2): 792-799

To ivestigate the effects of lower body positive pressure (LBPP) on kidney function while controlling certain cardiovascular and endocrine responses, seven men [35 .+-. 2 (SE) yr] underwent 30 min of sitting and then 4.5 h of head-up tilt. An antigravity suit was applied (60 Torr legs, 30 Torr abdomen) during the last 3 h of tilt. A similar noninflation experiment was conducted where the suited subjects were tilted for 3.5 h. To provide adequate urine flow, the subjects were hydrated during the course of both experiments. Immediately after inflation, mean arterial pressure increased by 8 .+-. 3 Torr and pulse rate decreased by 16 .+-. 3 beats/min. Plasma renin activity and aldosterone were maximally suppressed (P < 0.05) after 2.5 h of inflation. Plasma vasopressin decreased by 40-50% (P < 0.05) and plasma sodium and potassium remained unchanged during both experiments. Glomerular filtration rate was not increased significantly by inflation, whereas inflation induced marked increases (P < 0.05) in effective renal plasma flow (ERPF), urine flow, osmolar and free water clearances, and total and fractional sodium excretion. No such changes occurred during control. Thus, LBPP induces 1) a significant increases in ERPF and 2) significant changes in kidney excretory patterns similar to those observed during water immersion or the early phase of bed rest, situations that alos result in central vascular volume expansion.

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Accession: 007027497

Download citation: RISBibTeXText

PMID: 2708208

DOI: 10.1016/0883-9441(89)90019-1

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