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Apolipoprotein B messenger RNA editing is developmentally regulated in pig small intestine: nucleotide comparison of apolipoprotein B editing regions in five species


Apolipoprotein B messenger RNA editing is developmentally regulated in pig small intestine: nucleotide comparison of apolipoprotein B editing regions in five species



Biochemical and Biophysical Research Communications 173(1): 74-80



ISSN/ISBN: 0006-291X

PMID: 2256939

DOI: 10.1016/s0006-291x(05)81023-x

Apolipoprotein B (apo B) mRNA undergoes a posttranscriptional tissue-specific editing reaction which changes codon 2153 from glutamine (CAA) in apoB-100 mRNA to an in-frame stop codon (UAA) in apoB-100 mRNA to an in-frame stop codon (UAA) in apoB-48 mRNA. Small intestinal apo B mRNA was found to be predominantly (> 90%) unedited in fetal (40-day gestational age) piglets but >95% edited in neonatal, suckling and adult animals. By contrast, both fetal, neonatal and adult pig liver contained >99% unedited, apo B-100 mRNA. The nucleotide sequence spanning the edited region in apo B mRNA was found to be highly conserved. We speculate that the the regulation of apo B mRNA editing may be developmentally modulated in pig small intestine.

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Accession: 007030608

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