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Asymmetric diels alder reactions with gamma functionalized alpha beta unsaturated chiral n acyloxazolidinones synthesis of dextro s 145

Asymmetric diels alder reactions with gamma functionalized alpha beta unsaturated chiral n acyloxazolidinones synthesis of dextro s 145

Journal of Organic Chemistry 55(17): 5065-5073

An extension of the asymmetric Diels-Alder cycloaddition with chiral .gamma.-substituted, .alpha.,.beta.-unsaturated imides is described. The application of these results to the synthesis of the potent TxA2 receptor antagonist (+)-S-145 was successfully achieved in a practical manner.

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Accession: 007041102

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