+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Bacteriological, pharmacokinetic and clinical studies on cefpodoxime proxetil in the pediatric field



Bacteriological, pharmacokinetic and clinical studies on cefpodoxime proxetil in the pediatric field



Japanese Journal of Antibiotics 42(7): 1593-1606



Bacteriological, pharmacokinetic and clinical studies on cefpodoxime proxetil (CPDX-PR, CS-807), a new oral cephem antibiotic, were carried out in the field of pediatrics. The results obtained are summarized as follows. 1. Antibacterial activities of R-3746 (Na-salt of cefpodoxime (CPDX) against clinically isolated strains of Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, Enterococcus faecalis, Branhamella catarrhalis, Escherichia coli, Proteus mirabilis and Haemophilus influenzae were compared with those of cefaclor, cephalexin and cefadroxil. R-3746 is superior to other antibiotics against S. pneumoniae, S. pyogenes, B. catarrhalis and Gram-negative rods. 2. Serum concentrations of CPDX after administration of CPDX-PR at doses of 3 mg/kg (fasting), 6 mg/kg (non-fasting) and 6 mg/kg (fasting) were determined. Mean AUC (area under curve)'s of CPDX obtained were 9.60, 31.35 and 17.89 .mu.g .cntdot. hr/ml, respectively for the 3 dosages. The mean half-livers, of CPDX were 3.35, 1.88 and 1.76 hours, respectively. The mean urinary recovery rate within 8 hours after administration of CPDX-PR at a dose of 3 mg/kg (fasting) was 39.2%. 3. CPDX-PR was administered to 37 pediatric patients with various bacterial infections (pyelonephritis 9, cystitis 4, pneumonia, 7 acute bronchitis 3, otitis media 2, tonsillitis 10, subcutaneous abscess 1 and purulent lymphadenitis 1). The overall clinical efficacy rate was 91.9% and the overall bacteriological eradiation rate was also 91.9%. 4. No adverse reactions were observed. Abnormal laboratory findings were moderate, eosinophilia in 2 and slight elevation of GOT and GPT in 1. The taste and the odor of the CPDX-PR preparation was sufficiently tolerable. From the above results we have concluded that CPDX-PR is a useful oral antibiotic in the treatment of bacterial infections in children.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 007049232

Download citation: RISBibTeXText

PMID: 2562789


Related references

Pharmacokinetic, bacteriological and clinical studies on cefpodoxime proxetil in the field of pediatrics. Japanese Journal of Antibiotics 42(7): 1547-1560, 1989

Pharmacokinetic and clinical studies on cefpodoxime proxetil dry syrup in the field of pediatrics. Japanese Journal of Antibiotics 42(7): 1629-1666, 1989

Pharmacokinetic, bacteriological and clinical evaluation of cefpodoxime proxetil in pediatrics. Japanese Journal of Antibiotics 42(7): 1571-1592, 1989

Clinical studies of cefpodoxime proxetil in pediatric field. Japanese Journal of Antibiotics 42(7): 1477-1487, 1989

Laboratory and clinical studies of cefpodoxime proxetil in pediatric field. Japanese Journal of Antibiotics 42(7): 1607-1620, 1989

Pharmacokinetic and tolerance studies of cefpodoxime after single- and multiple-dose oral administration of cefpodoxime proxetil. Journal of Clinical Pharmacology 31(12): 1137-1145, 1991

The clinical study of cefpodoxime proxetil dry syrup preparation in the pediatric field. Japanese Journal of Antibiotics 47(9): 1202-1209, 1994

Clinical studies on cefpodoxime proxetil in the pediatric fields. Japanese Journal of Antibiotics 42(7): 1471-1476, 1989

Clinical evaluation of cefpodoxime proxetil in the treatment of skin and soft tissue infections. A double blind comparison of cefpodoxime proxetil and cefaclor. Japanese Journal of Antibiotics 41(10): 1517-1537, 1988

In vitro antimicrobial activities of lactoferrin, its concomitant use with cefpodoxime proxetil and clinical effect of cefpodoxime proxetil. Japanese Journal of Antibiotics 46(6): 482-485, 1993

Clinical studies on cefpodoxime proxetil dry syrup in the field of pediatrics. Japanese Journal of Antibiotics 42(7): 1621-1628, 1989

Clinical and bacteriological evaluation of cefpodoxime proxetil in acne vulgaris. Hifu 40(3): 311-315, 1998

Microbiological and clinical studies on cefpodoxime proxetil for bacterial skin and soft tissue infections in pediatric patients. Journal of ChemoTherapy 7(Suppl. 4): 124-126, 1995

Evaluation of cefpodoxime proxetil in the pediatric field. Japanese Journal of Antibiotics 42(7): 1505-1518, 1989

Clinical and pharmacokinetic evaluation of cefpodoxime proxetil in children. Japanese Journal of Antibiotics 42(7): 1456-1463, 1989