Bacteriostatic and bactericidal activities of gentamicin alone and in combination with clarithromycin against Mycobacterium avium

Heifets, L.B.; Lindholm-Levy, P.J.; Comstock, R.D.

Antimicrobial Agents and ChemoTherapy 36(8): 1695-1698

1992


ISSN/ISBN: 0066-4804
PMID: 1416852
DOI: 10.1128/aac.36.8.1695
Accession: 007049413

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Abstract
The inhibitory activity of gentamicin against Mycobacterium avium depended on the pH of the medium, and the broth-determined MICs for 90% of strains were 5.0 micrograms/ml at pH 7.4, 9.5 micrograms/ml at pH 6.8, and greater than 16.0 micrograms/ml at pH 5.0. The MBCs were two- to eightfold higher than the MICs. The combined effect of gentamicin and clarithromycin was additive, and the MICs and MBCs of each drug were either the same as those in the single-drug tests or reduced twofold.