+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Bronchial sensitization in guinea pigs following ingestion of ovalbumin

Bronchial sensitization in guinea pigs following ingestion of ovalbumin

International Archives of Allergy and Applied Immunology 90(4): 395-399

Local bronchial mucosal hypersensitivity following antigen feeding was studied in the guinea pig. Groups of 6 animals were fed 1% ovalbumin (OA) in tap water or tap water without antigen (control group) for different feeding periods (14, 28, 42, and 56 days). Inhalative provocations with increasing concentrations of OA (0.5-8% OA) were performed at the end of each feeding period followed by body plethysmographic measurement of airway obstruction. Specific bronchial hypersensitivity to inhaled OA was not found in the control group, whereas specific bronchial reactivity to OA, described as reactivity index, was significantly different from the control group after 14 (p less than 0.05), 28 (p less than 0.001) and 42 days (p less than 0.01) of feeding. No difference to the control group was found after 56 days of feeding. Anti-OA IgG total and IgG1 in serum and bronchoalveolar lavage fluid were increased in OA-fed animals reaching maximal concentrations at day 28 of the feeding period. We conclude that oral feeding of a 1% solution of OA can induce a transient state of local hypersensitivity to inhaled antigen in the guinea pig as manifested by bronchoconstriction on OA inhalation and increased concentrations of local and systemic specific antibodies. This period of local hypersensitivity is followed by tolerance.

(PDF emailed within 1 workday: $29.90)

Accession: 007071126

Download citation: RISBibTeXText

PMID: 2613345

Related references

Induction of bronchial asthma in guinea pigs gp following ingestion of ovalbumin oa. European Journal of Pediatrics 147(2): 223, 1988

Effects of estradiol on the course of ovalbumin sensitization in guinea pigs. Acta Pharmacologica Sinica 14(1): 49-51, 1993

Effects of ozone on ovalbumin sensitization in guinea pigs. Journal of Microbiology, Immunology, and Infection 31(4): 225-232, 1999

Effect of a combination of 3 pesticides on the sensitization of guinea pigs to ovalbumin. Eksperimentalna Meditsina i Morfologiia 18(1): 22-24, 1979

Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs. Journal of Applied Physiology 99(5): 1782-1788, 2005

Effect of respiratory syncytial virus on subsequent allergic sensitization to ovalbumin in guinea-pigs. European Respiratory Journal 13(5): 976-982, 1999

Passive sensitization of human skin by sera of guinea pigs anaphylactically sensitized to ovalbumin. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 77(2): 245-247, 1951

Effects of sensitization to ovalbumin on the lipid content of the bronchoalveolar lavage fluid in guinea pigs. Bulletin Europeen de Physiopathologie Respiratoire 21(4): 331-338, 1985

Secretory phospholipase A-2 activity is elevated bronchoalveolar lavage fluid after ovalbumin sensitization of guinea pigs. Journal of Leukocyte Biology 60(6): 704-709, 1996

Ovalbumin sensitization of guinea-pigs reduces fMLP-induced calcium signal in alveolar macrophages. Life Sciences 69(14): 1597-1607, August 24, 2001

The mechanism of airway hyperresponsiveness following immediate bronchial response in ovalbumin (OA)-sensitized guinea pigs. Arerugi 40(2): 164-167, 1991

Tracheal responsiveness to methacholine and ovalbumin; and lung inflammation in guinea pigs exposed to inhaled lead after sensitization. Ecotoxicology and Environmental Safety 86: 233-238, 2013