Ceftizoxime concentrations in human aqueous humor following intravenous administration

Martinelli, D.; Mazzei, T.; Fallani, S.; Palendri, G.; Novelli, A.; Periti, P.

Chemioterapia International Journal of the Mediterranean Society of ChemoTherapy 7(5): 317-319


ISSN/ISBN: 0392-906X
PMID: 3224400
Accession: 007085267

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the aqueous humor penetration of the third-generation cephalosporin, ceftizoxime, was determined in 21 patients awaiting cataract extraction, after an intravenous bolus injection of 2 g. The .beta.-lactam compound achieved a mean peak aqueous humor concentration of 7.8 mg/l two hours after administration with a serum/humor percent ratio ranging between 7 and 16% during the four-hour sampling interval. Therefore, ceftizoxime levels in this extravascular fluid were above the minimum inhibitory concentrations for the majority of sensitive organisms.