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Cell mediated immune response in pig after mycoplasma hyopneumoniae infection effect of immunosuppression of pneumonia in pig induced by mycoplasma hyopneumoniae



Cell mediated immune response in pig after mycoplasma hyopneumoniae infection effect of immunosuppression of pneumonia in pig induced by mycoplasma hyopneumoniae



Journal of the Chinese Society of Veterinary Science 14(4): 267-274



The effect of immunosuppression on Mycoplasma hyopneumoniae infection was evaluated by comparing data from cyclophosphamide (cy) treated pigs (group 1), Cobalt-60 locally irradated pigs (group 2), antithymocyte serum (ATS) treated pigs (group 3), infected pigs (group 4) and noninfected healthy pigs (group 5). Thirteen 8 week-old specific pathogen free pigs were used for this study. In group 1, pigs were treated with intraperitoneal infections of 25mg of cy/kg of body weight and the dose was repeated 5 times at 3 days intervals. Circulating B-lymphocyte percentages were depleted by 60% and absolute B-lymphocyte counts by 85%. Circulating T-lymphocyte percentages were relatively unaffected by cy treatment, but absoluteT-cells counts were depressed by 40%. In group 2, pigs were locally exposed to 400 R of Cobalt-60 gamma radiation, T-lymphocyte percentages were depleted by 75% and absolute T-cell counts by 85%. Circulating B-cell percentages were not affected, but absolute B-cell counts were depressed by 60%. In group 3, pigs were given 30 ml of ATS intraperitoneally and the dose was repeated 5 times at 3 days intervals, no depletion was found no both B and T lymphocyte percentage, but absolute B and T cells count were depressed by 55% and 50% respectively. In group 4, both B and T lymphocyte percentages were slightly decreased at 5 days after infection; it suggested that the mycoplasma infection may result in a suppression of the host's immune responses during the early stage of disease. Three groups (1,2 and 3) of immunosuppressed pigs infected with infected with M. hyopneumoniae only (group 4). These data indicated that the immunosuppressed treatment can enhance the pathogenicity of M. hyopneumoniae infection pigs, and it may conclude that both B and T lymphocytes play important role in the containment of the M. hyopneumoniae infection.

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