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Changes in arterial plasma potassium and ventilation during exercise in man



Changes in arterial plasma potassium and ventilation during exercise in man



Respiration Physiology 78(3): 323-330



We have investigated the relationship between arterial plasma potassium ([K+]a) and ventilation (.ovrhdot.VE) in man because hyperkalaemia has been shown to increase .ovrhdot.VE in the anaesthetized cat by direct stimulation of the arterial chemoreceptors. Six healthy male volunteers undertook a bout of sub-maximal (100 W) and maximal (sprint ca. 350 W) exercise on a cycle ergometer. .ovrhdot.VE was measured breath-by-breath and arterial blood was sampled at regular intervals from a catheter inserted into a brachial artery for measurement of [K+]a and base excess. Changes in [K+]a closely mirrored changes in .ovrhdot.VE during exercise and recovery. AT 100 W [K+]a increased from 4 mM to 5 mM, and during the sprint [K+]a increased to ca. 7 mM. Base excess did not mirror .ovrhdot.VE in that it reached its nadir 1-3 min after exercise had stopped, when [K+]a and .ovrhdot.VE were both falling. The increases in [K+]a seen here are probably sufficient to enhance the arterial chemoreceptor drive during exercise. Furthermore, the close temporal relationship between [K+]a and .ovrhdot.VE suggests that it is possible that exercise hyperkalaemia may contribute to the control of breathing in exercise.

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Accession: 007091343

Download citation: RISBibTeXText

PMID: 2616927

DOI: 10.1016/0034-5687(89)90107-2


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