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Changes in protein synthesis protein degradation and nucleic acid content in response to the beta adrenergic agonist clenbuterol in muscle of rats

, : Changes in protein synthesis protein degradation and nucleic acid content in response to the beta adrenergic agonist clenbuterol in muscle of rats. Archiv fuer Tierzucht 35(4): 421-429

The present study was designed to determine the effect of clenbuterol, a beta-adrenergic agonist, on muscle growth, protein synthesis, activity of calcium-dependent proteinase (CDP) as well as nucleic acid- and protein content in different muscles of rats. Clenbuterol administered orally as a feed additive (5 and 18 ppm respectively) for 12 days increased growth rate of the rats only slightly, but had a significant effect on muscle weights (19-25%). The protein synthesis studied using a cell-free translation assay was reduced in parts. Total protein content (7 - 25%) and RNA content (25 %) were increased. The DNA content remained unchanged. CDP-activity was reduced by 10 - 14% significantly upon clenbuterol feeding. The possible mode of action of clenbuterol was discussed to be caused by stimulated protein synthesis on the pretranslational level and inhibited calcium-dependent protein degradation. Both effects seem to be responsible for the observed muscle hypertrophy demonstrated by decreased nucleus-cytoplasm-ratios (24 - 28%).

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