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Changes in the blood serum proteins after experimental poisoning with alpha amanitin and phalloidin



Changes in the blood serum proteins after experimental poisoning with alpha amanitin and phalloidin



Mediko-Biologichni Problemi 17: 79-84



By means of dimeric immunoelectrophoresis and disc-electrophoresis in polyacrylamide gel the changes in the blood serum proteins were followed up after experimental poisoning of rabbits with sublethal doses of alpha-amanitin. Substantial changes in the concentration of 7 different proetins were found, the direction and extent of changes considerably differing according to the administered toxin. In the animals, injected with phalloidin, the disturbance in the blood serum profile begins as early as on the 3rd hour, while those with alph-amanitin - scarcely at the 10th hour following the introduction of the toxin. The possibilities for practical utilizing of the obtained results in the diagnostics of the phalloid poisonings are discussed.

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