+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Characterization of polyethylene glycols using differential scanning calorimetry

Characterization of polyethylene glycols using differential scanning calorimetry

International Journal of Pharmaceutics 74(1): 33-42

The melting behaviour of a range of different molecular weight polyethylene glycol (PEG) samples has been studied using differential scanning calorimetry (DSC). It was demonstrated that the shape of the endotherm was sensitive to the sample particle size, while the heat of fusion and melting points of the samples varied with scanning speed. Using standardised conditions, the PEG samples were solidified from the melt either by controlled cooling at 5 K/h or by immersing the sample in liquid nitrogen. The endotherms obtained indicated that the thermal history may determine both the degree of crystallinity and the crystal form of the polyethylene glycols, as shown by changes in the heat of fusion and melting points respectively. Studies using solid state nuclear magnetic resonance supported the conclusions drawn from the DSC studies. The study has therefore indicated that DSC is a suitable technique for detecting solid state changes in polyethylene glycols, thus facilitating standardisation of these materials.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 007102914

Download citation: RISBibTeXText

Related references

Characterization of polyethylene glycol solid dispersions using differential scanning calorimetry and solution calorimetry. International Journal of Pharmaceutics 76(1-2): 17-24, 1991

Characterization of polyethylene glycols using solution calorimetry. International Journal of Pharmaceutics 74(1): 43-48, 1991

Insight into the molecular arrangement of high-density polyethylene polymer chains in blends of polystyrene/highdensity polyethylene from differential scanning calorimetry and Raman techniques. Applied Spectroscopy 60(5): 483-489, 2006

Evaluation of Polyethylene-terephthalate Products of Chemical Recycling by Differential Scanning Calorimetry. Journal of Polymers and the Environment 17(1): 20-27, 2009

Characterization of polyethylene glycols and polypropylene glycols by capillary zone electrophoresis and micellar electrokinetic chromatography. Journal of Chromatography. a 985(1-2): 479-491, 2003

A differential scanning calorimetry study of retrieved orthopedic implants made of ultrahigh molecular weight polyethylene. Journal of Biomedical Materials Research 33(2): 73-82, 1996

Separation of polyethylene glycols and amino-terminated polyethylene glycols by high-performance liquid chromatography under near critical conditions. Journal of Chromatography. a 1447: 122-128, 2016

Separation of polyethylene glycols and maleimide-terminated polyethylene glycols by reversed-phase liquid chromatography under critical conditions. Journal of Separation Science 39(22): 4305-4313, 2016

Contribution to the Analysis of Polyethylene Glycols and their Monoethers by Partition Chromatography of their 3,5-Dinitrobenzoic Esters. I. Polyethylene Glycols. Journal of Chromatography 14: 209-227, 1964

Characterization of -trypsin at acid pH by differential scanning calorimetry. Brazilian Journal of Medical and Biological Research 36(12): 1621-1627, 2003

Use of differential scanning calorimetry in the thermal characterization of meat. Progress in refrigeration science and technology proceedings of the XIV International Congress of Refrigeration = Progres dans la science et la technique du froid: comptes rendus du XIV Congres international du froid edited by the Organizing Committee and the Papers Committee XIV International Congress of Refrigeration USSR National Committee for IIR: 314, 1979

Morphology characterization of emulsions by differential scanning calorimetry. Advances in Colloid and Interface Science 117(1-3): 59-74, 2005

Application of Differential Scanning Calorimetry at the characterization of the virgin olive oil. Grasas y Aceites 54(4): 403-409, 2003

Characterization of the thermal properties of magnetite using differential scanning calorimetry. Abstracts of Papers Submitted to the Lunar and Planetary Science Conference 32(Pages (abstr, 2001

Differential scanning calorimetry characterization of oxidized egg phosphatidylcholine liposomes. Biochemical & Biophysical Research Communications 168(3): 1268-1273, 1990