Circulating immune complexes containing chlamydial lipopolysaccharide in acute myocardial infarction
Leinonen, M.; Linnanmäki, E.; Mattila, K.; Nieminen, M.S.; Valtonen, V.; Leirisalo-Repo, M.; Saikku, P.
Microbial Pathogenesis 9(1): 67-73
1990
ISSN/ISBN: 0882-4010
PMID: 2077346
DOI: 10.1016/0882-4010(90)90042-o
Accession: 007116398
The presence of circulating immune complexes (IC) was studied using two detection methods specific for chlamydial lipopolysaccharide (LPS) in paired serum samples of 44 patients (30 men and 14 women) with acute myocardial infarction (AMI). Forty-four random controls were individually matched for locality, age and sex with the AMI patients. As specificity controls for the IC assays single serum samples from 29 patients with diseases characterized by the presence of circulating IC were used. Fifty-seven per cent of AMI patients, 12% of their random controls and 10% of the patient controls were shown to have chlamydial LPS-specific immune complexes in their sera (P < 0.0001, AMI versus random and patient controls). This finding provides further evidence of the possible association of chronic chlamydial infection with AMI.