+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Clinical study of a new fecal occult blood test using a combination assay of hemoglobin and transferrin



Clinical study of a new fecal occult blood test using a combination assay of hemoglobin and transferrin



Gastroenterologia Japonica 26(2): 151-156



The applicability of a new immunological fecal occult blood test in which hemoglobin (Hb) and transferrin (Tf) are simultaneously assayed was evaluated. The mean absorbance and standard deviation (510/630 nm) obtained by this test was 0.840 .+-. 0.805 in 51 fecal samples from patients with colon cancer, 0.248 .+-. 0.305 inn 95 samples from patients with colon polyps, and 0.104 .+-. 0.053 in 110 samples from control patients; these values differed significantly (P < 0.005). Hb and Tf concentrations were separately determined in the same fecal samples, and qualitative evaluation was performed with a cutoff value of 5.1 .mu.g/g feces for Hb and 0.4 .mu.g/g feces for Tf. Hb or Tf was positive in 41 of the 51 samples in the colon cancer group, 33 of the 95 in the colon polyp group, and 3 of the 110 in the control group. Qualitative analysis of the values obtained by the combination assay of Hb and Tf with a cutoff value of 0.200 revealed positive rates of 41/51 in the colon cancer group, 33/95 in the colon polyp group, and 4/110 in the control group. These results suggest the usefulness of a combination assay of Hb and Tf as a fecal occult blood test.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 007122824

Download citation: RISBibTeXText

PMID: 2040398

DOI: 10.1007/bf02811073


Related references

A new immunochemical fecal occult blood test--combination assay of hemoglobin and transferrin. Rinsho Byori. Japanese Journal of Clinical Pathology 37(1): 58-62, 1989

Development of a Combined Human Transferrin-Hemoglobin Lateral Immunochromatographic Assay for Accurate and Rapid Fecal Occult Blood Test. Clinical Laboratory 64(5): 805-813, 2018

Immunological determination of fecal hemoglobin and transferrin levels: a comparison with other fecal occult blood tests. American Journal of Gastroenterology 87(1): 67-73, 1992

Transferrin dipstick as a potential novel test for colon cancer screening: a comparative study with immuno fecal occult blood test. Cancer Epidemiology, Biomarkers & Prevention 18(8): 2182-2185, 2009

Comparison of a brush-sampling fecal immunochemical test for hemoglobin with a sensitive guaiac-based fecal occult blood test in detection of colorectal neoplasia. Cancer 109(9): 1925-6; Author Reply 1926, 2007

Comparison of a brush-sampling fecal immunochemical test for hemoglobin with a sensitive guaiac-based fecal occult blood test in detection of colorectal neoplasia. Cancer 107(9): 2152-2159, 2006

A higher detection rate for colorectal cancer and advanced adenomatous polyp for screening with immunochemical fecal occult blood test than guaiac fecal occult blood test, despite lower compliance rate. A prospective, controlled, feasibility study. International Journal of Cancer 128(10): 2415-2424, 2011

An immunological test for fecal occult blood by counter immunoelectrophoresis. Falsepositive reaction due to non-hemoglobin proteins in the tests with an anti-crude hemoglobin antibody. Nihon Shokakibyo Gakkai Zasshi 79(10): 1944-1949, 1982

Colorectal cancer screening: comparison of transferrin and immuno fecal occult blood test. World Journal of Gastroenterology 18(21): 2682-2688, 2012

Fecal degradation of hemoglobin effect on an immunochemical test for occult blood. Gastroenterology 98(5 PART 2): A319, 1990

Clinical study on monoheme an immunological fecal occult blood test reagent. Journal of the Japan Society of Coloproctology 40(3): 308-313, 1987

Combination of colonoscopy and fecal occult blood test. Harefuah 145(11): 843-843, 2006

An immunological test for fecal occult blood by counter immunoelectrophoresis: second report. Comparison in sensitivity to detect hemoglobin and positive reactions immunodiffusion and hemoccult test. Nihon Shokakibyo Gakkai Zasshi 81(12): 2935-2939, 1984

Clinical study on latex agglutination reaction for immunological fecal occult blood test. Journal of Tokyo Medical College 46(2): 269-278, 1988

Clinical study on the fecal occult blood test for mass screening of colo rectal cancer. Journal of the Japan Society of Coloproctology 36(2): 119-124, 1983