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Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity



Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity



Psychopharmacology 105(4): 453-458



The behavioral effects of racemic mianserin, its (+) and (-) enantiomers, and its metabolites desmethylmianserin and 8-hydroxymianserin were evaluated on the differential-reinforcement-of-low-rat 72-s (DRL 72-s) schedule, a screen known to be sensitive to and specific for the antidepressant properties of drugs. Racemic mianserin produced the antidepressant-like effect (increased reinforcement rate, decreased response rate) at 5 and 10 mg/kg. The mianserin enantiomers showed the antidepressant-like effect beginning at lower doses [+) mianserin; 0.6 mg/kg; (-) mianserin: 2.5 mg/kg]. The mainserin metabolites showed no clear dose-related effect at doses up to 10 mg/kg. It is concluded that the antidepressant-like effects of mianserin are due to the activity of the parent compound rather than to its metabolites, and that they may be primarily attributable to the (+) enantiomer. The greater potency of (+)-mianserin may be related to its higher affinity for the 5-HT2 receptor.

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Accession: 007143247

Download citation: RISBibTeXText

PMID: 1771213

DOI: 10.1007/bf02244363


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