Comparison of the effects of nifedipine and nicardipine on renal hemodynamics and cardiovascular hemodynamics with enflurane
Journal of Kyoto Prefectural University of Medicine 98(12): 1219-1226
Cardiovascular and renal effects of nifedipine and nicardipine were studied in mongrel dogs anaesthetized with 1.5% enflurane. The administration of intravenous nifedipine (5 .mu.g/kg/min) and nicardipine (5 .mu.g/kg/min) decreased blood pressure, heart rate, pulmonary vascular resistance and rate pressure product, but increased right atrial pressure, mean pulmonary artery pressure, pulmonary capillary wedge pressure and cardiac output due to reduction of systemic vascular resistance. Nicardipine decreased renal blood flow significantly (P < 0.05), but nifedipine did not change renal blood flow for 30 min after administration. Renal cortical blood flow significantly (P < 0.05) decreased after administration of nifedipine, but nicardipine did not change renal cortical blood flow. Plasma renin activity increased significantly (P < 0.05) after administration of nifedipine. The results indicate that the effects of nifedipine and nicardipine on cardiovascular hemodynamics are almost similar, while the effects on renal hemodynamic changes are different.