+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparison of the tolerance and efficacy of ketoprofen oruvail and ibuprofen brufen in patients with rheumatoid arthritis and osteo arthritis a randomized double blind cross over trial



Comparison of the tolerance and efficacy of ketoprofen oruvail and ibuprofen brufen in patients with rheumatoid arthritis and osteo arthritis a randomized double blind cross over trial



Clinical Trials Journal 27(3): 196-202



A randomized, double-blind, cross-over study is presented which assessed the comparative tolerane to, and efficacy of, a controlled-release formulation of ketoprofen (Oruvail) and ibuprofen (Brufen) in patients with rheumatoid arthritis and osteo-arthritis. A total of 44 patients were allocated at random to treatment with either controlled-release ketoprofen capsules 2 .times. 100 mg o.d. or ibuprofen tablets 400 mg t.i.d. for three weeks. After a one-week placebo wash-out period, each patient received the alternate treatment for a futher three weeks. However, seven patients dropped out at Day 7 and hence were not analysed further. Adverse effects occurred in five patients receiving controlled-release ketoprofen and eight receiving ibuprofen. Epigastric pain was reported by three patients during each treatment regimen, including the wash-out period. Controlled release ketoprofen was more effective than ibuprofen in reducing both pain severity and the duration of inactivity stiffness, and it appeared more beneficial in reducing severity of morning stiffness. The patients also considered controlled-release ketoprefen more effective than ibuprofen. It is concluded that controlled-release ketoprofen is more effective than ibuprofen in the treatment of rheumatoid arthitis and osteoarthritis, although both drugs were equally well tolerated.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 007144015

Download citation: RISBibTeXText


Related references

Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid arthritis patients. European Journal of Rheumatology and Inflammation 4(1): 93-96, 1981

A double-blind cross-over 12-month study of L-thyroxine treatment of women with 'subclinical' hypothyroidism. Clinical Endocrinology 29(1): 63-75, 1988

Double blind multi center comparison of 1200 milligram and 1000 milligram cimetidine in hospitalized and ambulatory duodenal ulcer patients. American Journal of Gastroenterology 76(6): 500-505, 1981

Efficacy and safety of ketamine in refractory status epilepticus in children. Neurology 79(24): 2355-2358, 2012

Multicenter double-blind randomized clinical trial of imidazole salicylate versus ibuprofen in patients with osteoarthrosis. International Journal of Clinical Pharmacology Therapy and Toxicology 25(9): 479-482, 1987

Therapeutic effects on disorders of spermatogenesis in hyperprolactinemia without pituitary adenoma. Fortschritte der Medizin 95(32): 1984-1986, 1977

Ketoprofen in the treatment of rheumatisms. Revista Espanola de Reumatismo Y Enfermedades Osteoarticulares 21(1): 90, 1978

S-heterochromatin in the evolution of the mammalian karyotype. Doklady Akademii Nauk SSSR 234(4): 935-937, 1977

Clinical evaluation of keto profen (Orudis) in rheumatoid arthritis: results of a multi-centre double-blind trial against phenylbutazone. Rheumatology and Rehabilitation Suppl: 43-44, 1976

Comparison of the efficacy and safety profile of morning administration of controlled-release simvastatin versus evening administration of immediate-release simvastatin in chronic kidney disease patients with dyslipidemia. Clinical Therapeutics 36(8): 1182-1190, 2014

Clinical evaluation of ketoprofen (Orudis) in rheumatoid arthritis. Results of a multi-centre, double-blind, cross-over trial against phenylbutazone. Scandinavian Journal of Rheumatology. Supplement 1976: 119-122, 1976

A case of West syndrome with a deletion at chromosome 2q24.3-q31.3. No to Hattatsu 49(2): 131-135, 2017

Efficacy of melatonin on offspring liver maturation in pinealectomized pregnant rats subjected to experimental epilepsy. Journal of Gastroenterology and Hepatology 22(4): 585-591, 2007

Comparison of the clinical efficacy and safety of salmeterol/fluticasone propionate versus current care in the management of persistent asthma in Korea. Current Medical Research and Opinion 24(12): 3571-3582, 2008

Comparison of the CHAMP radio occultation data with the Canadian advanced digital ionosonde in the Polar Regions. Advances in Space Research 44(11): 1304-1308, 2009