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Comparison of the tolerance and efficacy of ketoprofen oruvail and ibuprofen brufen in patients with rheumatoid arthritis and osteo arthritis a randomized double blind cross over trial

Comparison of the tolerance and efficacy of ketoprofen oruvail and ibuprofen brufen in patients with rheumatoid arthritis and osteo arthritis a randomized double blind cross over trial

Clinical Trials Journal 27(3): 196-202

A randomized, double-blind, cross-over study is presented which assessed the comparative tolerane to, and efficacy of, a controlled-release formulation of ketoprofen (Oruvail) and ibuprofen (Brufen) in patients with rheumatoid arthritis and osteo-arthritis. A total of 44 patients were allocated at random to treatment with either controlled-release ketoprofen capsules 2 .times. 100 mg o.d. or ibuprofen tablets 400 mg t.i.d. for three weeks. After a one-week placebo wash-out period, each patient received the alternate treatment for a futher three weeks. However, seven patients dropped out at Day 7 and hence were not analysed further. Adverse effects occurred in five patients receiving controlled-release ketoprofen and eight receiving ibuprofen. Epigastric pain was reported by three patients during each treatment regimen, including the wash-out period. Controlled release ketoprofen was more effective than ibuprofen in reducing both pain severity and the duration of inactivity stiffness, and it appeared more beneficial in reducing severity of morning stiffness. The patients also considered controlled-release ketoprefen more effective than ibuprofen. It is concluded that controlled-release ketoprofen is more effective than ibuprofen in the treatment of rheumatoid arthitis and osteoarthritis, although both drugs were equally well tolerated.

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Accession: 007144015

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