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Competition for overlapping sites in the regulatory region of the drosophila gene krueppel



Competition for overlapping sites in the regulatory region of the drosophila gene krueppel



Science 256(5053): 94-97



A 730-base pair element regulates expression of the Drosophila gap gene Kruppel (kr) in response to the fly anterior morphogen bicoid (bcd). Two hormone receptor-like proteins, encoded by the genes knirps (kni) and tailless (tll), bind specifically to the element. In vitro, kni protien competes with the homeodomain-containing bcd protein in binding to a 16-base pair target sequence. In vivo experiments suggest that both kni and tll act as competitive repressors of bcd-mediated activation of Kr. These results suggest a mechanism by which developmental genes can be regulated in responses to an activating morphogen gradient antagonized by repressors.

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Accession: 007145418

Download citation: RISBibTeXText

PMID: 1348871

DOI: 10.1126/science.1348871


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