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Complete amino acid sequence of rat kidney ornithine aminotransferase: identity with liver ornithine aminotransferase


Complete amino acid sequence of rat kidney ornithine aminotransferase: identity with liver ornithine aminotransferase



Journal of Biochemistry 108(1): 133-138



ISSN/ISBN: 0021-924X

PMID: 2229004

DOI: 10.1093/oxfordjournals.jbchem.a123152

The complete amino acid sequence of rat kidney ornithine aminotransferase [EC 2.6.1.13] is presented. The 404-residue sequence was determined by analysis of peptides generated by digestion of the S-carboxyamidomethylated protein with CNBr, Achromobacter protease I, arginylendopeptidase, or Staphylococcus aureus V8 protease. Mueckler and Pitot have reported the amino acid sequence of the rat liver enzyme (440 residues) as predicted from the nucleotide sequence of the cDNA [Mueckler, M.M. & Pitot, H.C. (1985) J. Biol. Chem. 260, 12993-12997]. The amino acid sequence of the rat kidney enzyme presented herein coincides with residue 36 (Gly) through 440 (Phe) of the predicted precursor protein, indicating that the liver and kidney enzymes are identical, and that the enzyme is processed at the amino-terminal region after translation.

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Accession: 007146294

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