Concentrations of bgh igf i insulin and nefa in blood plasma as well as bgh and igf i in milk of dairy cows after application of recombinant bovine growth hormone part 6. influence of bgh on energy and protein metabolism of dairy cows at different stages of lactation

Schams, D.; Schwab, W.; Kirchgessner, M.

Journal of Animal Physiology and Animal Nutrition 65(3-4): 126-132


ISSN/ISBN: 0931-2439
Accession: 007150077

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Bovine growth hormone (bGH), insulin like growth factor I (IGF-I), insulin and free fatty acids (NEFA) were measured in blood plasma on dairy cows treated with a slow release preparation of bGH (somidobove of Lilly Deutschland GmbH, Abteilung Elanco, 640 mg/28 d s.c.). Additionally bGH and IGF-I in milk were determined. Concentrations of bGH increased 4-fold until day 3 after injection and decreased to basal levels on days 10-12. IGF-I and NEFA were positively correlated to bGH. Insulin did not change significantly during treatment in contrast to NEFA which increased clearly. That means that the animals could compensate the lack of energy by mobilization of body fat. This indicates that there did not exist any physiological energy deficit by application of bGH despite of negative energy balance. Changes of bGH, IGF-I and NEFA were positively correlated to the amount of milk yield and milk fat production. There was no clear transfer to bGH or IGF-I into milk measurable.